Results 141 to 150 of about 1,861,365 (381)

TREM1/3 deficiency impairs tissue repair after acute kidney injury and mitochondrial metabolic flexibility in tubular epithelial cells [PDF]

, 2019
Long-term sequelae of acute kidney injury (AKI) are associated with incomplete recovery of renal function and the development of chronic kidney disease (CKD), which can be mediated by aberrant innate immune activation, mitochondrial pathology, and ...
Borrelli, Cristiana, Butter, Loes M, Claessen, Nike, Colonna, Marco, Dessing, Mark C, Florquin, Sandrine, Leemans, Jaklien C, Rampanelli, Elena, Scantlebery, Angelique M.L, Soriani, Alessandra, Tammaro, Alessandra   +10 more
core   +2 more sources

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

ING Proteins in Cellular Senescence

Current Drug Targets, 2009
Cellular senescence is an effective anti-tumor barrier that acts by restraining the uncontrolled proliferation of cells carrying potentially oncogenic alterations. ING proteins are putative tumor suppressor proteins functionally linked to the p53 pathway and to chromatin regulation.
Menéndez, Camino, Abad, María, Gómez-Cabello, Daniel, Moreno, Alberto, Palmero, Ignacio   +4 more
openaire   +4 more sources

High-resolution temporal profiling of transcripts during Arabidopsis leaf senescence reveals a distinct chronology of processes and regulation [PDF]

, 2011
Leaf senescence is an essential developmental process that impacts dramatically on crop yields and involves altered regulation of thousands of genes and many metabolic and signaling pathways, resulting in major changes in the leaf.
Beynon, Jim, Breeze, Emily, Buchanan-Wollaston, Vicky, Denby, Katherine J., Harrison, Elizabeth, Hickman, Richard J., Hill, Claire, Hughes, Linda Karen, Jackson, Stephen D., Jenkins, Dafyd J., Jenner, Carol E., Kiddle, Steven J., Kim, Youn-sung, Legaie, Roxane, McHattie, Stuart, Mead, A., Moore, Jonathan D., Morris, Karl, Ott, Sascha, Penfold, Christopher A., Rand, D. A., Tabrett, Alex, Thomas, Brian, Wild, David L., Zhang, Cunjin   +24 more
core   +3 more sources

Biological and technical complexities in analyzing extracellular vesicle immune interactions in B‐cell malignancies

FEBS Letters, EarlyView.
Daniel Bachurski, Michael Hallek
wiley   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Senescence and Cellular Immortality

, 2017
Cellular senescence is a state of irreversible growth arrest activated by a number of oncogenic signals. The senescence program prevents tumorigenesis via both cell and non-cell autonomous mechanisms. However, senescent cells accumulate and persist in the body during aging or following elevated genotoxic stress.
Demaria, Marco, Velarde, Michael C.
openaire   +1 more source

Sprouty1 is a broad mediator of cellular senescence

Cell Death and Disease
Genes of the Sprouty family (Spry1-4) restrain signaling by certain receptor tyrosine kinases. Consequently, these genes participate in several developmental processes and function as tumor suppressors in adult life.
Carlos Anerillas, Aida Perramon-Güell, Gisela Altés, Sara Cuesta, Marta Vaquero, Anna Olomí, Ruth Rodríguez-Barrueco, David Llobet-Navàs, Joaquim Egea, Xavi Dolcet, Andrée Yeramian, Mario Encinas   +11 more
doaj   +1 more source

Integrin Beta 3 Regulates Cellular Senescence by Activating the TGF-β Pathway

Cell Reports, 2017
Cellular senescence is an important in vivo mechanism that prevents the propagation of damaged cells. However, the precise mechanisms regulating senescence are not well characterized.
Valentina Rapisarda, Michela Borghesan, Veronica Miguela, Vesela Encheva, Ambrosius P. Snijders, Amaia Lujambio, Ana O’Loghlen   +6 more
doaj   +1 more source

CDK2 and CKI targeting can significantly lower the cellular senescence bar - reveals a mathematical model of G1/S checkpoint pathway [PDF]

, 2010
Cellular senescence, a mechanism employed by cells for thwarting proliferation, has shown to play an important role in protecting cells against cancer development in recent experimental observations, indicating that a deeper understanding of the cellular
Don Kulasiri, Hong Ling, Sandhya Samarasinghe   +2 more
core