Results 121 to 130 of about 1,093,681 (262)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

No clear benefit of cellular therapy consolidation for patients achieving remission after post-HCT AML relapse. [PDF]

Blood Adv
Murdock HM, Kim HT, Maurer K, Kelkar A, Shapiro RM, Gooptu M, Romee R, Nageshwar PK, Garrity HM, Shimony S, Luskin MR, Winer ES, Vedula RS, Stahl M, Chen EC, Volpe V, Garcia JS, Wadleigh M, DeAngelo DJ, Stone RM, Wu CJ, Cutler CS, Koreth J, Ritz J, Antin JH, Ho VT, Nikiforow S, Soiffer RJ.   +27 more
europepmc   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Adoptive cellular therapy prevents reconstitution of myeloid-derived suppressor cells in the glioma tumor microenvironment. [PDF]

Neurooncol Adv
Figg JW, Love C, Stansbury S, Jin D, Francis C, Dean BD, Reid A, Engelbart M, West I, Font LF, Feier D, Ebrahim G, Bessey R, Hilferty D, Yegorov O, Yang C, Long-James K, Mitchell DA, Flores CT.   +18 more
europepmc   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Highlighting the CORD-SaFe Trial From Melbourne-Progress Toward Cellular Therapy in Extremely Preterm Newborns. [PDF]

Pediatr Discov
Bhatt A, Nimbalkar S, Patel D, Pujara R.
europepmc   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

P1313: PREDICTING OUTCOMES IN AML PATIENTS CONSOLIDATED BY AN ALLOGENEIC STEM CELL TRANSPLANTATION USING THE KNOWLEDGE BANK APPROACH

HemaSphere, 2022
M. Jentzsch, L. Herrmann, L. Bischof, D. Backhaus, D. Brauer, G.-N. Franke, V. Vucinic, U. Platzbecker, S. Schwind   +8 more
doaj   +1 more source

Cellular and gene therapy

HemaSphere, 2019
openaire   +3 more sources

Editorial: Cellular Therapies in Cancer [PDF]

Frontiers in Immunology, 2019
Hind Rafei, Rohtesh S. Mehta, Katayoun Rezvani   +2 more
openaire   +3 more sources