Results 71 to 80 of about 2,335,939 (309)
Size-dependent cellular uptake of exosomes [PDF]
Nanomedicine: Nanotechnology, Biology and Medicine, 2017 The ability of exosomes to elicit specific cellular responses suggests that they may be increasingly used as therapeutics. Their vesicular nature makes them suitable as potential nanocarriers for drugs or nucleic acids delivery. Here we address the question whether the method of preparation of enriched exosomal fractions can affect their uptake by ...
Caponnetto, Federica +7 more
openaire +4 more sources
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Bioactive Materials, 2018 In order to improve the release pattern of chemotherapy drug and reduce the possibility of drug resistance, poly(ethylene glycol amine) (PEG)-modified alginate microparticles (ALG-PEG MPs) were developed then two different mechanisms were employed to ...
Tianmu Hu +5 more
doaj +1 more source
Cellular Uptake of Biotin: Mechanisms and Regulation [PDF]
The Journal of Nutrition, 1999 This review describes our knowledge of biotin transport in the small intestine of humans and other mammals and presents recent findings in the area. Previous studies have shown that biotin transport across the brush border membrane of the small intestinal absorptive cells occurs via a carrier-mediated, Na+ gradient-dependent, electroneutral mechanism ...
openaire +2 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Nanomaterials, 2015 We studied the physico-chemical properties (size, shape, zeta-potential), cellular internalization and toxicity of gold nanoparticles (NPs) stabilized with the most abundant mammalian protein, collagen.
Oana T. Marisca +7 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Rotaxanes as Cages to Control DNA Binding, Cytotoxicity and Cellular Uptake of a Small Molecule [PDF]
, 2020 In this paper we report a unique approach to control the DNA interactions, cellular uptake and cellular localisation of a small molecule. We have designed rotaxanes that include a luminescent DNA binder, a macrocycle that modulates the DNA binding and a ...
Ramon, Vilar +4 more
core +2 more sources
Cellular uptake mechanism and intracellular fate of hydrophobically modified pullulan nanoparticles
International Journal of Nanomedicine, 2013 Liqin Jiang,1 Xuemin Li,1 Lingrong Liu,1 Qiqing Zhang1,21Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, People's Republic of China; 2Research Center of Biomedical Engineering ...
Jiang L, Li X, Liu L, Zhang Q
doaj
Uptake rate of cationic mitochondrial inhibitor MKT-077 determines cellular oxygen consumption change in carcinoma cells. [PDF]
PLoS ONE, 2012 OBJECTIVE:Since tumor radiation response is oxygen-dependent, radiosensitivity can be enhanced by increasing tumor oxygenation. Theoretically, inhibiting cellular oxygen consumption is the most efficient way to increase oxygen levels.
John L Chunta +3 more
doaj +1 more source