Results 81 to 90 of about 2,335,939 (309)

Cellular uptake and intracellular trafficking of oligonucleotides [PDF]

Advanced Drug Delivery Reviews, 2015
Oligonucleotides manifest much promise as potential therapeutic agents. However, understanding of how oligonucleotides function within living organisms is still rather limited. A major concern in this regard is the mechanisms of cellular uptake and intracellular trafficking of both 'free' oligonucleotides and oligonucleotides associated with various ...
R L, Juliano, K, Carver
openaire   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Nanoparticle-based intra-cellular diagnostics [PDF]

, 2012
An in-depth understanding of biochemical processes occurring within the cell is a key factor for early diagnosis of disease and identification of appropriate treatment.
Korzeniowska, Barbara
core   +1 more source

Cellular Uptake of Phase‐Separating Peptide Coacervates

Advanced Science
Peptide coacervates self‐assembling via liquid‐liquid phase separation are appealing intracellular delivery vehicles of macromolecular therapeutics (proteins, DNA, mRNA) owing to their non‐cytotoxicity, high encapsulation capacity, and efficient cellular
Anastasia Shebanova, Quentin Moana Perrin, Kexin Zhu, Sushanth Gudlur, Zilin Chen, Yue Sun, Congxi Huang, Zhi Wei Lim, Evan Angelo Mondarte, Ruoxuan Sun, Sierin Lim, Jing Yu, Yansong Miao, Atul N. Parikh, Alexander Ludwig, Ali Miserez   +15 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Optimization of Polyarginine-Conjugated PEG Lipid Grafted Proliposome Formulation for Enhanced Cellular Association of a Protein Drug

Pharmaceutics, 2019
The purpose of this study was to develop an oral proliposomal powder of protein using poly-l-arginine-conjugated 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-poly(ethylene glycol) (DSPE-PEG) (PLD) for enhancing cellular association upon reconstitution
Amolnat Tunsirikongkon, Yong-Chul Pyo, Dong-Hyun Kim, Sang-Eun Lee, Jeong-Sook Park   +4 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Comparison of In vitro Nanoparticles Uptake in Various Cell Lines and In vivo Pulmonary Cellular Transport in Intratracheally Dosed Rat Model

Nanoscale Research Letters, 2008
In present study, the potential drug delivery of nanoformulations was validated via the comparison of cellular uptake of nanoparticles in various cell lines and in vivo pulmonary cellular uptake in intratracheally (IT) dosed rat model. Nanoparticles were
Chiang Po-Chang, Blom Jason, Li Na, Shevlin Kimberly, Brayman Timothy, Hu Yiding, Selbo Jon, Hu LiangbiaoGeorge, Lai Yurong   +8 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Cellular localization, accumulation and trafficking of double-walled carbon nanotubes in human prostate cancer cells [PDF]

, 2012
Carbon nanotubes (CNTs) are at present being considered as potential nanovectors with the ability to deliver therapeutic cargoes into living cells. Previous studies established the ability of CNTs to enter cells and their therapeutic utility, but an ...
Silva, S. Ravi P., Coley, Helen M., Neves, V, Flahaut, E, Gerondopoulos, Andreas, Heister, Elena, Neves, Vera, Tîlmaciu, Carmen, Coley, HM, Flahaut, Emmanuel, Gerondopoulos, A, Heister, E, McFadden, J, McFadden, Johnjoe, Soula, Brigitte, Soula, B, Tîlmaciu, C, Silva, SRP   +17 more
core   +1 more source