Results 151 to 160 of about 1,087 (181)
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Biocatalytic enantioselective synthesis of cenobamate, an antiepileptic drug
ChiralityAbstract A green and efficient process for the synthesis of cenobamate has been accomplished in 70% yield and >99% ee through the bio‐reduction of β ‐ketotetrazole using Daucus carota ...
Vennapusa Haritha +7 more
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Steps towards seizure freedom with the use of Cenobamate
Epilepsy & BehaviorCenobamate (CNB) is an antiseizure medication (ASM) that may change the prescription across the time. Our study sought to compare the rate of seizure-freedom patients after one year of CNB use experience in a single tertiary centre.All patients with a minimum follow-up of one year who used CNB between 2021 and 2022 (n = 66) were compared to those who ...
M, Toledo +8 more
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Cenobamate‐associated weight loss (Cenobaweight study)
EpilepsiaAbstractRationaleData on weight changes associated with Cenobamate (CNB) in patients with epilepsy is scarce. We performed a case‐control study because of concern for clinically significant weight loss.MethodsAll patients exposed to CNB between its May in February 2020 until October 2023 with at least 180 days of exposure were evaluated.
Jafar Hashem +6 more
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Effectiveness and tolerability of cenobamate: A single center experience
Epilepsy ResearchMedication-resistant epilepsy (MRE) is characterized by the failure of adequate trials of two antiseizure medications (ASMs). Numerous studies have shown that once two ASMs fail to control seizures, the likelihood of subsequent ASM regimens providing seizure control diminishes significantly. Recent clinical data on cenobamate (CNB) suggest it may offer
Christopher, Saouda +7 more
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A Phase 1 Clinical Study Evaluating the Effects of Cenobamate on the QT Interval
Clinical Pharmacology in Drug Development, 2022Philip T Sager, Marc Kamin, Hongqi Xue
exaly
Sudden Unexpected Death in Epilepsy During Cenobamate Clinical Development
Epilepsia, 2023Wesley T. Kerr +2 more
exaly