Results 141 to 150 of about 16,570,594 (297)
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
International Journal of CommunicationThe digital public sphere is characterized by seemingly paradoxical tensions between centers and peripheries: While some actors leverage the affordances of digital platforms to garner attention and gain prominence in public discourse, others prefer to ...
Patrick Donges +2 more
doaj
Hassan Continues to Be Popular; Potential 2016 Gubernatorial Candidates Unknown 5/26/15 [PDF]
, 2015 Governor Maggie Hassan’s favorability and job approval continues to be high among New Hampshire residents. Four potential 2016 candidates for governor are largely unknown by Granite Staters.
Survey Center, UNH
core +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Home Stretch: Trump Keeps Lead 2/7/16 [PDF]
, 2016 With only days remaining, Donald Trump still holds the lead in the New Hampshire Primary race and most Republican voters think he will win the primary.
Survey Center, UNH
core +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Lynch Heads Into Final Year With High Approval Ratings, Concerns About Economy Remain 2/6/2012 [PDF]
, 2012 Entering his last year in office, New Hampshire Governor John Lynch’s job approval rating remains very high. Economic problems continue to be the top concerns for Granite Staters, but have moderated somewhat in recent ...
Survey Center, UNH
core +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Bush Disapproval Near All-Time High 2/7/2008 [PDF]
, 2008 Entering his final year in office, President George W. Bush remains very unpopular in New Hampshire.
Survey Center, UNH
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source