Results 111 to 120 of about 4,623,308 (321)
Bifurcation of Nongeneric Homoclinic Orbit Accompanied by Pitchfork Bifurcation
Abstract and Applied Analysis, 2014 The bifurcation of a nongeneric homoclinic orbit (i.e., the orbit comes from the equilibrium along the unstable manifold instead of the center manifold) connecting a nonhyperbolic equilibrium is investigated, and the nonhyperbolic equilibrium undergoes ...
Fengjie Geng, Song Li
doaj +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Stability and Hopf Bifurcation Analysis of a Gene Expression Model with Diffusion and Time Delay
Abstract and Applied Analysis, 2014 We consider a model for gene expression with one or two time delays and diffusion. The local stability and delay-induced Hopf bifurcation are investigated.
Yahong Peng, Tonghua Zhang
doaj +1 more source
The McCance Brain Care Score and Mortality: Evidence From a Large‐Scale Population‐Based Cohort
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives This study aimed to examine the relationship between the McCance Brain Care Score (BCS) and mortality in the general population. Methods We conducted a prospective, population‐based cohort study using data from the UK Biobank. Participants with complete data enabling calculation of BCS and full mortality information were included ...
Zhiqiang Xu, Xiaoxiao Wang, Nan Li
wiley +1 more source
Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky +8 more
wiley +1 more source
Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron +5 more
wiley +1 more source
NeuroImage: ClinicalBrain connectome analysis provides insights into body mass index (BMI)-related brain topology and cognitive functions. While alterations in the brain connectome have been observed in individuals with high BMI, evidence regarding BMI-based structural ...
Yurim Jang +3 more
doaj +1 more source
Stability and Hopf Bifurcation Analysis of Coupled Optoelectronic Feedback Loops
Abstract and Applied Analysis, 2013 The dynamics of a coupled optoelectronic feedback loops are investigated. Depending on the coupling parameters and the feedback strength, the system exhibits synchronized asymptotically stable equilibrium and Hopf bifurcation.
Gang Zhu, Junjie Wei
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. Methods CSF and plasma were collected (longitudinally when available) from AxD participants and non‐AxD controls.
Amy T. Waldman +9 more
wiley +1 more source