Results 91 to 100 of about 64,085 (304)

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

A formal series approach to the center manifold theorem

, 2017
International audienceThis paper considers near-equilibrium systems of ordinary differential equations with explicit separation of the slow and stable manifolds.
Sauzeau, Julie, F. Castella, Ph. Chartier, Castella, François, Chartier, Philippe, J. Sauzeau   +5 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Erratum to: Center Manifold Method in the Asymptotic Integration Problem for Functional Differential Equations with Oscillatory Decreasing Coefficients. II (in Russian)

Моделирование и анализ информационных систем, 2016
We correct the computational mistakes in paper: Nesterov P. N. Center Manifold Method in the Asymptotic Integration Problem for Functional Differential Equations with Oscillatory Decreasing Coefficients. II. In: Modeling and Analysis of Information Systems.
P. N. Nesterov
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Mechanical Entropy and Its Implications

Entropy, 2001
: It is shown that the classical laws of thermodynamics require that mechanical systems must exhibit energy that becomes unavailable to do useful work. In thermodynamics, this type of energy is called entropy.
Pharis E. Williams
doaj   +1 more source

Center manifold for autonomous and nonautonomous differential equations

, 2013
Darbā ir aplūkota Lipšica gludas centra varietātes eksistence autonomam un neautonomam diferenciālvienādojumām. Tika uzrakstīts pierādījums centra varietātes eksistences teorēmai, izmantojot materiālu no Jack Carr grāmatas "Applications of Centre ...
Kļimakova, Darja
core  

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Center manifold and stability in critical cases for some partial functional differential equations [PDF]

, 2006
24 pagesIn this work, we prove the existence of a center manifold for some partial functional differential equations, whose linear part is not necessarily densely defined but satisfies the Hille-Yosida condition. The attractiveness of the center manifold
Wu, Jianhong, Ezzinbi, Khalil, Adimy, Mostafa   +2 more
core  

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source