Results 51 to 60 of about 4,749,604 (246)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

On the orientability of the asset equilibrium manifold [PDF]

This paper addresses partly an open question raised in the Handbook of Mathematical Economics about the orientability of the pseudo-equilibrium manifold in the basic two-period General Equilibrium with Incomplete markets (GEI) model. For a broad class of
Philippe Bich
core   +2 more sources

Centers on center manifolds in a quadratic system obtained froma scalar third-order differential equation

Electronic Journal of Differential Equations, 2011
We give affirmative answers to two questions concerning the existence of centers on local center manifolds at equilibria of a quadratic system in the three dimensional space.
Warley Ferreira da Cunha, Fabio Scalco Dias, Luis Fernando Mello   +2 more
doaj  

The Stochastic Hopf Bifurcation and Vibrational Response of a Double Pendulum System Under Delayed Feedback Control

Mathematics
In this paper, we investigate the nonlinear dynamic behavior of a cart–double pendulum system with single time delay feedback control. Based on the center manifold theorem and stochastic averaging method, a reduced-order dynamic model of the system is ...
Ruichen Qi, Shaoyi Chen, Caiyun Huang, Qiubao Wang   +3 more
doaj   +1 more source

Stability and Bifurcation for a Delayed Diffusive Two-Zooplankton One-Phytoplankton Model with Two Different Functions

Complexity, 2021
In this paper, a diffusion two-phytoplankton one-zooplankton model with time delay, Beddington–DeAnglis functional response, and Holling II functional response is proposed.
Xin-You Meng, Li Xiao
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Pseudo-manifold geometries with applications [PDF]

, 2006
A Smarandache geometry is a geometry which has at least one Smarandachely denied axiom(1969), i.e., an axiom behaves in at least two different ways within the same space, i.e., validated and invalided, or only invalided but in multiple distinct ways and ...
Mao, Linfan, Linfan Mao
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Hopf bifurcations in a three-species food chain system with multiple delays

Open Mathematics, 2017
This paper is concerned with a three-species Lotka-Volterra food chain system with multiple delays. By linearizing the system at the positive equilibrium and analyzing the associated characteristic equation, the stability of the positive equilibrium and ...
Xie Xiaoliang, Zhang Wen
doaj   +1 more source

Center Manifold Method in the Asymptotic Integration Problem for Functional Differential Equations with Oscillatory Decreasing Coefficients. I

Моделирование и анализ информационных систем, 2014
In this paper, we study the asymptotic integration problem in the neighborhood of infinity for a certain class of linear functional differential systems. We construct the asymptotics for solutions of the considered systems in the critical case. Using the
P. N. Nesterov
doaj   +1 more source