Results 61 to 70 of about 4,623,308 (321)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Stability and Bifurcation for a Delayed Diffusive Two-Zooplankton One-Phytoplankton Model with Two Different Functions

Complexity, 2021
In this paper, a diffusion two-phytoplankton one-zooplankton model with time delay, Beddington–DeAnglis functional response, and Holling II functional response is proposed.
Xin-You Meng, Li Xiao
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Center manifold and exponentially-bounded solutions of a forced Newtonian system with dissipation

Electronic Journal of Differential Equations, 2000
We study the existence of exponentially-bounded solutions to the following system of second-order ordinary differential equations with dissipation: $$ u''+cu'+Au+kH(u) = P(t), quad u in {mathbb R}^n, quad t in {mathbb R}, $$ where $c$ and $k$ are ...
Luis Garcia, Hugo Leiva
doaj  

Center Manifolds of Coupled Cell Networks [PDF]

SIAM Journal on Mathematical Analysis, 2017
Dynamical systems with a network structure can display anomalous bifurcations as a generic phenomenon. As an explanation for this it has been noted that homogeneous networks can be realized as quotient networks of so-called fundamental networks. The class of admissible vector fields for these fundamental networks is equal to the class of equivariant ...
Rink, B.W., Nijholt, E.C., Sanders, J.A.
openaire   +3 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Centers on center manifolds in a quadratic system obtained froma scalar third-order differential equation

Electronic Journal of Differential Equations, 2011
We give affirmative answers to two questions concerning the existence of centers on local center manifolds at equilibria of a quadratic system in the three dimensional space.
Warley Ferreira da Cunha, Fabio Scalco Dias, Luis Fernando Mello   +2 more
doaj  

Center Manifold Method in the Asymptotic Integration Problem for Functional Differential Equations with Oscillatory Decreasing Coefficients. I

Моделирование и анализ информационных систем, 2014
In this paper, we study the asymptotic integration problem in the neighborhood of infinity for a certain class of linear functional differential systems. We construct the asymptotics for solutions of the considered systems in the critical case. Using the
P. N. Nesterov
doaj   +1 more source

Dynamics and Chaos Control for a Discrete-Time Lotka-Volterra Model

IEEE Access, 2020
Bifurcation theory (center manifold and Ljapunov-Schmidt reduction, normal form theory, universal unfolding, calculation of bifurcation diagrams) has become an important and very useful means in the solution of nonlinear stability problems in many ...
Youping Lin, Qamar Din, Muhammad Rafaqat, Abdelalim A. Elsadany, Yanqiu Zeng   +4 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source