Results 101 to 110 of about 3,814,816 (395)

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

The effect of staggering a biplane [PDF]

open access: yes
This investigation was carried out by request of the United States Air Service at the Massachusetts Institute of Technology wind tunnel in 1918. As the data collected may be of general interest, they are published here by the National Advisory Committee ...
Norton, F H
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

The Center of Pressure in Peripheral Diabetic Neuropathy

open access: yes, 2017
Human upright posture is inherently unstable and requires control of the central integration of information from the three sensory systems: vestibular, visual and somatosensory.
Daissy Carola Toloza Cano
semanticscholar   +1 more source

The optimal design of standard gearsets [PDF]

open access: yes, 1983
A design procedure for sizing standard involute spur gearsets is presented. The procedure is applied to find the optimal design for two examples - an external gear mesh with a ratio of 5:1 and an internal gear mesh with a ratio of 5:1.
Coy, J. J., Savage, M., Townsend, D. P.
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Comparison of center-of-pressure displacement during sit-to-stand according to chair height in children with cerebral palsy

open access: yesJournal of Physical Therapy Science, 2015
[Purpose] In patients with cerebral palsy (CP), performance of the sit-to-stand (STS) task is influenced by an asymmetrical motor pattern. The purpose of this study was to analyze the effects of an elevated chair on STS performance in patients with CP ...
H. Lee, In-hee Lee
semanticscholar   +1 more source

SZE Observables, Pressure Profiles and Center Offsets in Magneticum Simulation Galaxy Clusters

open access: yes, 2016
We present a detailed study of the galaxy cluster thermal \ac{sze} signal $Y$ and pressure profiles using {\it Magneticum} Pathfinder hydrodynamical simulations.
Dolag, Klaus.   +4 more
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Parameters of the center of pressure displacement on the saddle during hippotherapy on different surfaces

open access: yesBrazilian Journal of Physical Therapy, 2015
Background: Hippotherapy uses horseback riding movements for therapeutic purposes. In addition to the horse's movement, the choice of equipment and types of floor are also useful in the intervention.
F. Flores   +3 more
semanticscholar   +1 more source

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