Results 81 to 90 of about 3,701,025 (306)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Controllable multicolor emission from initially non-emissive organic molecules by pressure engineering

Nature Communications
Developing smart luminescent materials with off-on switchable responsiveness, which enables dark-to-bright state transitions in response to external stimuli, has garnered great interest across various domains.
Zhihao Xiao, Weibin Wang, Jingkun Yu, Yunfeng Yang, Haifeng Zhu, Siyu Lu, Zhennan Wu, Xinyi Yang, Bo Zou   +8 more
doaj   +1 more source

Emergent superconductivity in an iron-based honeycomb lattice initiated by pressure-driven spin-crossover

Nature Communications, 2018
Up to now, all iron-based high-T c superconductors contain a square iron lattice. Here, Wang et al. report the observation of superconductivity in an iron honeycomb lattice accompanied with pressure-driven spin-crossover, in-plane lattice collapse and ...
Yonggang Wang, Jianjun Ying, Zhengyang Zhou, Junliang Sun, Ting Wen, Yannan Zhou, Nana Li, Qian Zhang, Fei Han, Yuming Xiao, Paul Chow, Wenge Yang, Viktor V. Struzhkin, Yusheng Zhao, Ho-kwang Mao   +14 more
doaj   +1 more source

Age-related changes in human posture control: Motor coordination tests [PDF]

Postural responses to support surface displacements were measured in 214 normal human subjects ranging in age from 7 to 81 years. Motor tests measured leg muscle Electromyography (EMG) latencies, body sway, and the amplitude and timing of changes in ...
Black, F. O., Peterka, R. J.
core   +1 more source

Observations on the Formation of Massive Stars by Accretion

, 2005
Observations of the H66a recombination line from the ionized gas in the cluster of newly formed massive stars, G10.6-0.4, show that most of the continuum emission derives from the dense gas in an ionized accretion flow that forms an ionized disk or torus
Bernasconi P., Downes D., Dyson J., Eric Keto, Henning T., Kahn F., Kenneth Wood, Larson R., Norberg P., Redman M., Testi L., Walmsley M., Yorke H.   +12 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Crystalline polymeric phases of sulphur dioxide

Communications Chemistry
SO2 is a molecule of significant industrial and geochemical importance, known for its role in sulphuric acid production and its natural occurrence in volcanic processes.
Huichao Zhang, Philip Dalladay-Simpson, Francesco Capitani, Cheng Ji, Li Zhang, Mario Santoro, Federico A. Gorelli, Roman Martoňák   +7 more
doaj   +1 more source

The optimal design of standard gearsets [PDF]

, 1983
A design procedure for sizing standard involute spur gearsets is presented. The procedure is applied to find the optimal design for two examples - an external gear mesh with a ratio of 5:1 and an internal gear mesh with a ratio of 5:1.
Coy, J. J., Savage, M., Townsend, D. P.
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

X-ray Tail in NGC 7619

, 2008
We present new observational results of NGC 7619, an elliptical galaxy with a prominent X-ray tail and a dominant member of the Pegasus group. With Chandra and XMM-Newton observations, we confirm the presence of a long X-ray tail in the SW direction ...
Awaki H., Balcells M., Bender R., Dong‐Woo Kim, Eunhyeuk Kim, Forbes D. A., Fukazawa Y., Gibson B. K., Ginevra Trinchieri, Giuseppina Fabbiano, Grevesse N, Rangarajan F. V. N., Trinchieri G.   +12 more
core   +1 more source