Results 91 to 100 of about 3,701,025 (306)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Equation of state and phonon frequency calculations of diamond at high pressures

, 2003
The pressure-volume relationship and the zone-center optical phonon frequency of cubic diamond at pressures up to 600 GPa have been calculated based on Density Functional Theory within the Local Density Approximation and the Generalized Gradient ...
A. Tardieu, A. Zunger, A.F. Goncharov, A.K. Ramdas, B.R. Wu, C. Hartwigsen, C. Mailhiot, C.-S. Zha, C.P. Herrero, D. Schiferl, E. Sjösted, E. Whalley, E.S. Zouboulis, F. Birch, F. Occelli, F.D. Murnaghan, F.D. Stacey, G. Kresse, G. Kresse, G. Kresse, G. Kresse, G.J. Piermarini, G.K.H. Madsen, H. Boppart, H.J. McSkimin, H.J. Monkhorst, H.K. Mao, H.K. Mao, I. Loa, I.V. Aleksandrov, I.V. Aleksandrov, J. Xie, J.J. Zhao, J.P. Perdew, J.P. Perdew, J.R. Chelikowsky, J.R. Chelikowsky, K. Kunc, K. Nakano, K. Syassen, M. Cardona, M. Hanfland, M. Muinov, M. Payne, M. Willatzen, M.H. Grimsditch, M.H. Grimsditch, M.L. Cohen, M.T. Yin, O. Grasset, O. Jepsen, O.H. Nielsen, O.H. Nielsen, O.H. Nielsen, P. Gillet, P. Hohenberg, P. Pavone, P. Vinet, P.E. Blöchl, P.E. Blöchl, P.E. Van Camp, R. Vogelgesang, S. Fahy, S. Fahy, S. Fahy, S. Fahy, S. Gaurav, S. Goedecker, S. Scandolo, S. Serra, S.J. Clark, S.S. Mitra, T. Sato, W. Kohn, W.B. Holzapfel, W.B. Holzapfel, W.F. Sherman, X. Gonze, X. Gonze   +78 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

MASTer: A high-performance stable temperature controller for high-pressure multi-anvil presses

Matter and Radiation at Extremes
Maintaining stable high temperatures under pressure remains a challenge in high-pressure, high-temperature experiments using multi-anvil presses (MAPs).
Guoliang Niu, Shengbo Cao, Bingmin Yan, Huiyang Gou, Tomoo Katsura, Ho-kwang Mao   +5 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Effect of nose bluntness and afterbody shape on aerodynamic characteristics of a monoplanar missile concept with bodies of circular and elliptical cross sections at a Mach number of 2.50 [PDF]

The tests were performed at a Mach number of 2.50 and at angles of attack from about -4 deg to 32 deg. The results indicate that increasing nose bluntness increases zero lift drag and decreases both the maximum lift-drag ratio and the level of ...
Fournier, R. H., Graves, E. B.
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Effect of boattail geometry on the acoustics of parallel baffles in ducts [PDF]

Sound attenuation and total pressure drop of parallel duct baffles incorporating certain boattail geometries were measured in the NASA Ames Research Center 7- by 10-Foot Wind Tunnel.
Dudley, M. R., Soderman, P. T., Unnever, G.   +2 more
core   +1 more source

Effect of pressure on the Raman modes of antimony

, 2006
The effect of pressure on the zone-center optical phonon modes of antimony in the A7 structure has been investigated by Raman spectroscopy. The A_g and E_g frequencies exhibit a pronounced softening with increasing pressure, the effect being related to a
G. Kresse, I. Loa, J. Donohue, J. Wittig, K. Kunc, K. Syassen, L. F. Vereshchagin, M. Kasami, M. S. Dresselhaus, M. V. Klein, O. Degtyareva, T. N. Kolobyanina, T. N. Kolobyanina, U. Schwarz, W. Richter, X. Wang   +15 more
core   +3 more sources