Results 71 to 80 of about 1,088,242 (267)

Approximation Algorithms for the Vertex K-Center Problem: Survey and Experimental Evaluation

IEEE Access, 2019
The vertex k-center problem is a classical NP-Hard optimization problem with application to Facility Location and Clustering among others. This problem consists in finding a subset $C \subseteq V$ of an input graph $G=(V,E)$ , such that the distance ...
Jesus Garcia-Diaz, Rolando Menchaca-Mendez, Ricardo Menchaca-Mendez, Saul Pomares Hernandez, Julio Cesar Perez-Sansalvador, Noureddine Lakouari   +5 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Exact solution approaches for the discrete α-neighbor p-center problem. [PDF]

Networks (N Y), 2023
Gaar E, Sinnl M.
europepmc   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

(n,1,1,∝)-Center Problem

, 2021
Given a set 𝑆 of 𝑛 points in the plane and a constant 𝛼,(𝑛, 1, 1, 𝛼)-center problem is to find two closed disks which each covers the whole 𝑆, the diameter of the bigger one is minimized, and the distance of the two centers is at least 𝛼. Constrained (𝑛, 1, 1, 𝛼)-center problem is the (𝑛, 1, 1, 𝛼)-center problem in which the centers are forced to lie ...
Kavand, P., Mohades, Ali, Eskandari, Marzieh   +2 more
openaire   +1 more source

Real‐World Investigation of Satralizumab in Patients With Neuromyelitis Optica Spectrum Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Satralizumab, a monoclonal antibody targeting the interleukin‐6 receptor, has demonstrated efficacy in clinical trials for neuromyelitis optica spectrum disorder (NMOSD). However, its real‐world effectiveness and safety compared to conventional immunosuppressive therapies remain uncertain.
Li‐Tsung Lin, Hui‐An Lin, Sheng‐Feng Lin   +2 more
wiley   +1 more source

Deep Learning–Assisted Differentiation of Four Peripheral Neuropathies Using Corneal Confocal Microscopy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peripheral neuropathies contribute to patient disability but may be diagnosed late or missed altogether due to late referral, limitation of current diagnostic methods and lack of specialized testing facilities. To address this clinical gap, we developed NeuropathAI, an interpretable deep learning–based multiclass classification ...
Chaima Ben Rabah, Ioannis N. Petropoulos, Mark Stettner, Maryam Ferdousi, Uazman Alam, Nathan Efron, Ahmed Serag, Rayaz A. Malik   +7 more
wiley   +1 more source

Qualitative Properties of k-Center Problems

Journal of Optimization Theory and Applications
In this paper, we study generalized versions of the k-center problem, which involves finding k circles of the smallest possible equal radius that cover a finite set of points in the plane. By utilizing the Minkowski gauge function, we extend this problem to generalized balls induced by various convex sets in finite dimensions, rather than limiting it ...
Vo Si Trong Long, Nguyen Mau Nam, Jacob Sharkansky, Nguyen Dong Yen   +3 more
openaire   +2 more sources

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source