Results 121 to 130 of about 3,380,250 (279)

Centering Neural Network Gradient Factors

open access: yes, 1997
It has long been known that neural networks can learn faster when their input and hidden unit activities are centered about zero; recently we have extended this approach to also encompass the centering of error signals [2]. Here we generalize this notion
Nicol N. Schraudolph
core  

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

An in vitro study of the ability of three new continuous rotary heat-treated nickel-titanium files to shape curved root canals

open access: yesAnnali di Stomatologia
Objectives: To compare the shaping ability of three new continuous rotary heat-treated nickel-titanium files in curved root canal. Methods: Sixty standard resin simulated root canals were randomly divided into three groups (n = 20): i-FILE X, Orodeka ...
Jimin Zhang   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

A method which can enhance the optical -centering accuracy

open access: yes, 2014
Optical alignment machining is an effective method to ensure the co-axiality of optical system. The co-axiality accuracy is determined by optical-centering accuracy of single optical unit, which is determined by the rotating accuracy of lathe and the ...
Zhang, Xue-Min   +5 more
core  

Inviting Response(ability): Developing a Learning-centered Homiletic

open access: yes
Chapter 1 introduces the theme of this study: namely, how following a learning-centered pedagogy as the core pedagogical strategy for preaching reimagines preaching theologically, epistemologically, and practically. The aim of this study is to develop a learning-centered homiletic by which the participants are invited to practice their response(ability)
openaire   +2 more sources

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

open access: yesFEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana   +3 more
wiley   +1 more source

Optional vena cava filter with disengaging centering struts: retrieval in an animal model

open access: yes, 2008
An optional inferior vena cava (IVC) filter prototype was evaluated for safety and long-term retrievability as an initial feasibility study in an animal model.
Keller, Frederick S   +6 more
core   +1 more source

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