Results 101 to 110 of about 16,200,897 (373)
FEBS Letters, EarlyView.We achieved cytoplasmic delivery of non‐cell‐penetrating IgGs by grafting a single functional complementarity‐determining region 1 (CDR1) from the light chain variable region (VL) of the cell‐internalizable 3D8 antibody. The engineered IgG acquired cell‐penetrating ability while maintaining antigen affinity, highlighting CDR1 grafting as a promising ...
Yerin Jeon +5 more
wiley +1 more source
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
Mechanisms Underlying Overactive Bladder and Interstitial Cystitis/Painful Bladder Syndrome
Frontiers in Neuroscience, 2018 The bladder is innervated by extrinsic afferents that project into the dorsal horn of the spinal cord, providing sensory input to the micturition centers within the central nervous system.
Luke Grundy +5 more
doaj +1 more source
On the Centrality of Jurisprudence [PDF]
The American Journal of Jurisprudence, 2019 Political communities typically organise themselves by an appeal to values. Sometimes the values invoked are abstract ideas such as justice or equality. One such idea is that of law. In many important instances, practices cannot be understood except by reference to the values to which they make an implicit appeal but from which they fall short; and ...
openaire +3 more sources
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
FEBS Letters, EarlyView.Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
Rare odontogenic tumor of the mandible
Journal of Indian Academy of Oral Medicine and Radiology, 2008 Central odontogenic fibroma is an extremely rare benign tumor accounting for less than 0.1% of all odontogenic tumors. This case report describes a case of central odontogenic fibroma arising in relation to the left lower second premolar and first molar ...
V Vaishnavee +3 more
doaj +1 more source
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
On universal central extensions of Hom-Lie algebras [PDF]
arXiv, 2012 We develop a theory of universal central extensions of Hom-Lie algebras. Classical results of universal central extensions of Lie algebras cannot be completely extended to Hom-Lie algebras setting, because of the composition of two central extensions is not central.
arxiv
Education: Central to the Central Science [PDF]
Journal of Chemical Education, 2003 For our Children Sixty percent of high school students take chemistry; few will take it from a chemist.
openaire +2 more sources
How Central Should the Central Bank Be? [PDF]
Journal of Economic Literature, 2010 The nature and scope of the Federal Reserve's authority and the structure of its decision making are now “on the table” to an extent that has not been seen since 1935, and the Fed's vaunted independence is under some attack. This essay asks what the Federal Reserve should—and shouldn't—do, leaning heavily on the concept of economies of scope.
openaire +3 more sources