Results 201 to 210 of about 4,741,798 (267)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Central Venous Pressure Referencing in the Lateral Position: Comparison With Direct Right Atrial Pressure in Mechanically Ventilated ICU Patients. [PDF]

Acta Anaesthesiol Scand
Sjödin C, Oras J, Johansson L, Persson P, Olausson S, Holmqvist J, Ille A, Vidovic N, Svensson CJ.   +8 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Type I hair cells of striolar and central zones in vestibular organs are essential for head stability and postural control. [PDF]

Proc Natl Acad Sci U S A
Ono K, Lee HJ, Chang HHV, Verdone BM, Wafa T, Ji Y, Huang A, Fitzgerald T, Cullen KE, Wu DK.   +9 more
europepmc   +1 more source

Sensory Blurring in Nociplastic Pain: The Role of Descending Inhibitory Dysfunction and Gut-Brain Axis Alterations in Older Adults. [PDF]

Geriatrics (Basel)
Nagamine T.
europepmc   +1 more source

Cohort Profile: The Central Denmark Cancer Cohort. [PDF]

Clin Epidemiol
Vágó EK, Sørensen HT, Pedersen L, Horváth-Puhó E.   +3 more
europepmc   +1 more source

Rural Settlement in Central and Eastern Scotland: The Medieval Evidence

Scottish Studies, 1962
G. W. S. Barrow
doaj  

Distinct evolutionary trajectories of two integration centres, the central complex and mushroom bodies, across Heliconiini butterflies. [PDF]

Elife
Farnworth MS, Toh YP, Loupasaki T, Hodge EA, El Jundi B, Montgomery SH.   +5 more
europepmc   +1 more source

Burden of Ischemic Heart Disease in Central Asia from 1990 to 2021: A Systematic Analysis of the Global Burden of Disease Study 2021. [PDF]

Int J Environ Res Public Health
Davletov D, Kulimbet M, Makhmutov A, Osser D, Pashimov M, Assembekov B, Davletov K.   +6 more
europepmc   +1 more source