Results 71 to 80 of about 470,838 (198)

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Real-world challenges in hepatocellular carcinoma in Central America and the Caribbean: insights from a multinational expert survey. [PDF]

Front Oncol
Perelló C, Disla HJ, Coste P, Valdez M, Páez D, Rivera C, Loo Y, Mayorga T, Torres K, Pol E, Adames E, Mayo M, Morel LM, Gutierrez R, Calleja JL.   +14 more
europepmc   +1 more source

Mycobacterium abscessus scalp infection after hair transplantation in Central America. [PDF]

CMAJ, 2023
Chow I, Chan S, Lin M, Peters L.
europepmc   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Identification of Paragonimus mexicanus and P. caliensis in freshwater crabs from Costa Rica: evidence of zoonotic lung fluke diversity in Central America. [PDF]

PLoS Negl Trop Dis
Wehrtmann IS, Hernández-Chea R, Magalhães C, Dolz G, Zuniga Moya MJ, Romero-Chaves R, Villalobos-Rojas F.   +6 more
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Correction: Real-world challenges in hepatocellular carcinoma in Central America and the Caribbean: insights from a multinational expert survey. [PDF]

Front Oncol
Perelló C, Disla H, Coste P, Valdez M, Páez D, Rivera C, Loo Y, Mayorga T, Torres K, Pol E, Adames E, Mayo M, Morel L, Gutierrez R, Calleja JL.   +14 more
europepmc   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Overview of SARS-CoV-2 genomic surveillance in Central America and the Dominican Republic from February 2020 to January 2023: the impact of PAHO and COMISCA's collaborative efforts. [PDF]

Front Public Health
Herrera Agüero S, Sosa A, Martinez AA, Moreno A, Conde Pereira CR, Gonzalez C, Soto-Garita C, Ulate D, Cordero-Laurent E, Brenes H, Sánchez IM, Mendez-Rico J, Góndola J, Molina Mora JA, Leite J, Franco L, Mendoza L, Gresh L, De La Cruz L, Castro Paz M, Barahona M, Iihoshi N, Chavarría O, Born P, Aguillón RM, Vasquez Cordova RC, Gonzalez S, Alvarado Silva SC, Sandoval López X, Imbert Y, Duarte-Martínez F.   +30 more
europepmc   +1 more source