Results 111 to 120 of about 9,248,758 (286)

Salvianolic Acid a Disrupts the HSP90α‐AKT‐PERK Ternary Complex to Alleviate Atherosclerosis by Activating Endoplasmic Reticulum Stress of Senescent Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Salvianolic acid A (SAA) selectively induces senescent vascular smooth muscle cell apoptosis, alleviating atherosclerosis. Mechanistically, SAA targets heat shock protein 90 alpha (HSP90α) to disrupt the protein inase B (AKT)‐PRKR‐Like Endoplasmic Reticulum Kinase (PERK) scaffold, driving ubiquitin‐proteasome‐dependent AKT degradation.
Xiuya Guan, Mengkai Lu, Xinhai Cui, Dawei Zhang, Lei Zhang, Lin Lin, Yuan Li, Yuanlong Hu, Chao Li   +8 more
wiley   +1 more source

P6.19 PHYSIOLOGICAL CORRELATES OF AORTIC RESERVOIR AND EXCESS PRESSURE IN MAN

Artery Research, 2013
Background: Central (aortic) blood pressure (BP) indices independently predict cardiovascular events and all-cause mortality, but the physiological mechanisms underlying aortic BP waveform morphology are subject to debate.
M.G. Schultz, J.E. Davies, A. Hardikar, S. Pitt, A.D. Hughes, J.E. Sharman   +5 more
doaj   +1 more source

Comparison of Central Aortic Pressure between Women with Preeclampsia and Normotensive Postpartum Women from an Urban Region of Western Mexico. [PDF]

Medicina (Kaunas), 2023
Hernández-Mora FJ, Cerda-Guerrero CK, García-Benavides L, Cervantes-Pérez E, Ramírez-Ochoa S, Vázquez-Beltrán JC, Cervantes-Guevara G, Ledezma-Hurtado E, Nápoles-Echauri A, González-Ojeda A, Fuentes-Orozco C, Hernández-Rivas MI, Chávez-Tostado M, Cervantes-Cardona GA.   +13 more
europepmc   +1 more source

Ilexoside K Ameliorates Atherosclerosis by Suppressing CD72hi Macrophages and Blocking CXCL12–CXCR4 Axis to Inhibit Endothelial Pyroptosis

Advanced Science, EarlyView.
CD72hi macrophages drive endothelial pyroptosis and accelerate atherosclerosis through CXCL12–CXCR4‐mediated immune–vascular crosstalk. Ilexoside K suppresses this pathogenic communication by modulating CXCR4‐dependent endothelial responses, reducing inflammation and plaque progression. These findings reveal a macrophage–endothelial regulatory axis and
Xingling He, Sijing Li, Jiahui Chen, Liyu Lin, Xinyu Li, Xiaojiao Zhang, Yihui Zhang, Xingling Chen, Jinjian Guo, Zhongqi Yang, Lu Lu, Shihao Ni   +11 more
wiley   +1 more source

Central Aortic Pressure and Arterial Stiffness in Parkinson's Disease: A Comparative Study. [PDF]

Parkinsons Dis, 2022
Balal M, Demirkiran M, Paydas S.
europepmc   +1 more source

Associations and clinical relevance of aortic-brachial artery stiffness mismatch, aortic reservoir function, and central pressure augmentation [PDF]

, 2015
Central augmentation pressure (AP) and index (AIx) predict cardiovascular events and mortality, but underlying physiological mechanisms remain disputed.
Schultz, MG, Hughes, AD, Davies, JE, Sharman, JE   +3 more
core  

Wearable E‐Textiles for Cardiovascular Monitoring: Materials, Devices, and Integrated Systems

Advanced Science, EarlyView.
The graphical abstract highlights the role of conductive materials and textile fabrication techniques in enabling smart textiles for cardiovascular applications. It showcases textile‐based ECG monitoring, pulse sensing, hemodynamic monitoring, and cardiovascular tissue engineering, while emphasizing the challenges and design considerations that govern ...
Bangul Khan, Mahmoud Tavakoli, Norbert Radacsi, Bee Luan KHOO   +3 more
wiley   +1 more source

Wave reflection quantification analysis and personalized flow wave estimation based on the central aortic pressure waveform. [PDF]

Front Physiol, 2023
Sun H, Yao Y, Liu W, Zhou S, Du S, Tan J, Yu Y, Xu L, Avolio A.   +8 more
europepmc   +1 more source

Extracellular Vesicle Packaged TDP43 Derived From ECs Exacerbates Cigarette Tar‐Related Atherosclerosis Progression via Enhancing Macrophage Extracellular Traps

Advanced Science, EarlyView.
Cigarette tar triggers EC‐derived EVs carrying TDP43, which binds VDAC1 to boost MAMs, mitochondrial Ca2+ overload, and METs formation in macrophages, accelerating smoking‐related AS progression, while retinoic acid binds TDP43 to block this pathogenic cascade.
Xinxin Zhu, Yuwu Chen, Wei Meng, Biyi Xu, Junke Mou, Xiaolin Liu, Mengyang Wang, Qishuo Gu, Qianhui Sun, Man Li, Chen Zhao, Ming Zeng, Ying Lv, Boling Yi, Sheng Qu, Xiaoxuan Bai, Ji Li, Xing Luo, Sining Hu, Bo Yu, Haibo Jia   +20 more
wiley   +1 more source

Direct estimation of central aortic pressure from measured or quantified mean and diastolic brachial blood pressure: agreement with invasive records. [PDF]

Front Cardiovasc Med, 2023
Bia D, Salazar F, Cinca L, Gutierrez M, Facta A, Zócalo Y, Diaz A.   +6 more
europepmc   +1 more source