Results 101 to 110 of about 9,248,758 (286)

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

Advanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu, Hongkun Wang, Jiawei Wang, Xiaolu Liu, Aerziguli Aierken, Lizhen Xu, Ping Liang, Fan Yang   +7 more
wiley   +1 more source

Childhood Obesity Associates Haemodynamic and Vascular Changes That Result in Increased Central Aortic Pressure with Augmented Incident and Reflected Wave Components, without Changes in Peripheral Amplification

International Journal of Vascular Medicine, 2016
The aims were to determine if childhood obesity is associated with increased central aortic blood pressure (BP) and to characterize haemodynamic and vascular changes associated with BP changes in obese children and adolescents by means of analyzing ...
Juan M. Castro, Victoria García-Espinosa, Santiago Curcio, Maite Arana, Pedro Chiesa, Gustavo Giachetto, Yanina Zócalo, Daniel Bia   +7 more
doaj   +1 more source

Non-invasive central aortic pressure measurement: what limits its application in clinical practice? [PDF]

Front Cardiovasc Med, 2023
Diaz A, Zócalo Y, Salazar F, Bia D.
europepmc   +1 more source

Multimodal Imaging of Hypoxia, Metabolism and pH in Feline Sarcoma Using Hyperpolarized 13C MRI and PET

Advanced Science, EarlyView.
This work presents a clinically deployable simultaneous PET/MRI workflow which integrates hyperpolarized 13C imaging of metabolism and extracellular pH with [18F]FMISO PET to characterize hypoxia, acidosis, and metabolic reprogramming in feline sarcoma.
Martin Grashei, Tanja Groll, Stephanie Kahl, Silke Baer, Elisabeth Bliemsrieder, Frits H. A. van Heijster, Andre Wendlinger, Pascal Wodtke, Jorge Cabello, Susan Notohamiprodjo, Christian Lohrmann, Markus Schwaiger, Wolfgang A. Weber, Katja Steiger, Andrea Meyer‐Lindenberg, Johannes Hirschberger, Christine Baumgartner, Franz Schilling   +17 more
wiley   +1 more source

Blood Pressure and Cognitive Function

Psychological Science, 2013
Central (aortic) blood pressures differ from brachial pressures and may be more relevant to the study of cognitive function, given that blood is delivered to the brain through the central large arteries. Pulse-pressure amplification reflects the augmentation of blood pressure between the central and peripheral arteries, which diminishes with aging.
Pase, Matthew, Stough, Con, Grima, Natalie, Harris, Elizabeth, Macpherson, Helen, Scholey, Andrew, Pipingas, Andrew   +6 more
openaire   +4 more sources

Effectiveness of Chrono-Pharmacotherapy Depending on the Salt Sensitivity of Patients with Arterial Hypertension and Diabetes Mellitus Type 2

Рациональная фармакотерапия в кардиологии, 2019
Aim. To study the effect of two regimens of combined antihypertensive therapy during the day on daily monitoring of arterial pressure, central aortic pressure, and arterial stiffness, depending on the salt sensitivity of hypertensive patients with ...
V. V. Skibitskiy, A. A. Kiselev, A. V. Fendrikova   +2 more
doaj   +1 more source

Plant Metabolites Screening Identifies 7‐epi‐10‐Deacetyltaxol Inhibiting Cell Division by Interfering With the Cell Cycle and Microtubule Organization

Advanced Science, EarlyView.
In this study, an efficient screening system is developed for plant metabolites to find a compound, 7‐epi‐10‐deacetyltaxol, inhibits tissue elongation. It suppresses plant growth through brassinosteroid and microtubule pathways. It is later applied to animal cells and human tumor organoids, resulting in similar cell division suppression. These findings
Yan‐Jie Zhang, Yu‐Xuan Bai, Geng G. Tian, Bin Zhang, Ding‐Yi Lu, Qing‐Ping Yao, Wen‐Hao Tian, Xiao‐Na Wei, Jing‐Ting Yang, Ze‐Yu Xiong, Yi Lu, Yu‐Tong Jiang, Chun‐Hui Cai, Yu‐Ming Lu, Xian‐Qing Jia, Li‐Li Jing, Bao‐Jun Yang, Ying‐Xin Qi, Xin‐Xin Han, Ji Wu, Wen‐Hui Lin   +20 more
wiley   +1 more source

P6.10 A COMPARISON BETWEEN THE VICORDER AND SPHYGMOCOR DEVICES FOR THE NON-INVASIVE ASSESSMENT OF CENTRAL BLOOD PRESSURE

Artery Research, 2009
Background: There is increasing evidence that central (aortic) blood pressure (BP) may be a more important determinant of cardiovascular risk than brachial BP.
G. Pucci, L. Whittaker, S.S. Hickson, J. Cheriyan, G. Schillaci, C.M. McEniery, I.B. Wilkinson   +6 more
doaj   +1 more source

Commentary: Direct estimation of central aortic pressure from measured or quantified mean and diastolic brachial blood pressure: agreement with invasive records. [PDF]

Front Cardiovasc Med, 2023
Chemla D, Jozwiak M.
europepmc   +1 more source

The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII‐δ

Advanced Science, EarlyView.
UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Hai‐Lian Bi, Yu‐Hui Gu, Kai‐Wen Ren, Xiao‐Hong Yu, Yun‐Long Xia, Xiao‐Lei Yang, Hui‐Hua Li   +6 more
wiley   +1 more source