Results 81 to 90 of about 9,248,758 (286)

Central aortic pressure augmentation in stable renal transplant recipients [PDF]

Kidney International, 2002
Premature cardiovascular disease is the leading cause of death in renal transplant recipients and classical risk factors significantly underestimate the risk. The increased effect of arterial wave reflections on central arteries has recently been shown to be an important independent predictor of cardiovascular mortality in chronic hemodialysis patients.
Ferro, Charles J., Savage, Tessa, Pinder, Sarah J., Tomson, Charles R.V.   +3 more
openaire   +2 more sources

Central aortic blood pressure and augmentation index: comparison between Vasotens® and SphygmoCor® technology

Research Reports in Clinical Cardiology, 2012
Anatoliy N Rogoza,1 Aleksandr A Kuznetsov21Cardiology Research Complex, Moscow, Russian Federation; 2Therapy Research Institute, Siberian branch of Russian Academy of Medical Science, Novosibirsk, Russian FederationIntroduction: The aim of this study is ...
Rogoza AN, Kuznetsov AA
doaj  

Correlations between invasively measured aortic pressures and left ventricular end-diastolic pressure in patients undergoing coronary angiography

, 2019
Objective Data on ventricular-arterial coupling using invasive hemodynamic studies are limited. This study was performed to clarify the interaction between aortic pressures and left ventricular end-diastolic pressure (LVEDP) using invasive ...
Kim, Hack-Lyoung, Lim, Woo-Hyun, 김상현, Kang, Do-Yoon, Park, Seong-Hoon, Kim, Myung-A, Kim, Sang-Hyun, Seo, Jae-Bin, Zo, Joo-Hee, Kim, Kyung-Jin, 김경진   +10 more
core   +2 more sources

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source

P5.05 EXERCISE- INDUCED ALBUMINURIA IS A MANIFESTATION OF EXERCISE AORATIC RESERVOIR FUNCTION IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

Artery Research, 2013
Objectives: Patients with type 2 diabetes (T2DM) are susceptible to exercise-induced albuminuria even at submaximal exercise, but the mechanisms are unknown.
R.E.D. Climie, V. Srikanth, L.J. Keith, J.E. Davies, J.E. Sharman   +4 more
doaj   +1 more source

KLF5 Downregulation Links Impaired BNIP3‐Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease

Advanced Science, EarlyView.
In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian, Jia‐Xi Gu, Zhang Yue, Chun‐Ze Yuan, Hai‐Bin Ji, Ao Li, Yu Zhong, Xiu‐Fan Xu, Yu‐Qiu He, Ye‐Fan Jiang, Hong‐Shan Chen, Xiang Chen, Meng‐Lin Chao, Yong‐Feng Shao   +13 more
wiley   +1 more source

SerpinA3 is an Endogenous TGF‐β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling

Advanced Science, EarlyView.
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang, Jieyu Cui, Chunlu Huang, Wanyi Guo, Tong Liu, Yi Zhu, Shuai Shao, Kangyin Chen, Jinlong He, Qiankun Bao   +9 more
wiley   +1 more source

Central Aortic Blood Pressure and Management of Hypertension [PDF]

Hypertension, 2013
See related article, pp 1138–1145 Hypertension, a condition of elevated arterial blood pressure (BP) conventionally diagnosed by brachial cuff sphygmomanometry, is associated with increased risk of cardiovascular mortality and morbidity and end-organ damage.
openaire   +2 more sources

THSD7A Exacerbates Atherosclerosis via Activation of Signaling Axis αvβ3/CEBPD/IL1A

Advanced Science, EarlyView.
THSD7A exerts pro‐inflammatory effects and exacerbates atherosclerosis. Mechanistically, THSD7A regulates endothelial cell inflammation and atherosclerosis by activating the αvβ3/CEBPD/IL1A signaling axis. THSD7A is not only a genetic marker but also a potential therapeutic target for coronary artery disease (CAD).
Jiankun Liu, Hongfei Liu, Yiqi Wan, Andong Wu, Jiayu Qiu, Xueting Gong, Ya Zhao, Yuanyuan Li, Bingbing Zhou, Yangyi Zheng, Fang Wu, Yuanzheng Zhu, Weixin Lv, Xueer Li, Qiang Yuan, Xiao‐Li Tian   +15 more
wiley   +1 more source

The effects of central arterial pressure and autonomic dysfunction on elevations in N-terminal pro-B-type natriuretic peptide (NT-proBNP) in men with diabetes

Artery Research, 2008
Background: In diabetes, left ventricular dysfunction independent of coronary disease is common and is associated with elevations in NT-proBNP. Our aims were to determine the relative importance of central aortic pressure, cardiovascular autonomic ...
S. Bunce, A. Stride, C. Matthews, S. Shaw, J.C. Smith   +4 more
doaj   +1 more source