Results 91 to 100 of about 83,271 (257)

The E3 Ligase RNF115 Aggravates Pathological Cardiac Hypertrophy via Ubiquitin‐Mediated Degradation of SPTBN1

Advanced Science, EarlyView.
In response to hypertrophic stimuli, increased c‑JUN phosphorylation upregulates RNF115, leading to SPTBN1 ubiquitination and degradation. which promotes F‑actin depolymerization and YAP activation, driving cardiac hypertrophy. The RNF115 inhibitor DTD effectively suppresses SPTBN1 ubiquitination and cardiac hypertrophy.
Yan Zu, Shiqing Chen, Ji Chen, Liuliu Ruan, Bowen Li, Weijian Chu, Shichen Huang, Dian Yu, Jing Tian, Yuhan Zhao, Yi Han, Xin Tang, Yong Ji   +12 more
wiley   +1 more source

P6.19 PHYSIOLOGICAL CORRELATES OF AORTIC RESERVOIR AND EXCESS PRESSURE IN MAN

Artery Research, 2013
Background: Central (aortic) blood pressure (BP) indices independently predict cardiovascular events and all-cause mortality, but the physiological mechanisms underlying aortic BP waveform morphology are subject to debate.
M.G. Schultz, J.E. Davies, A. Hardikar, S. Pitt, A.D. Hughes, J.E. Sharman   +5 more
doaj   +1 more source

Commentary: Direct estimation of central aortic pressure from measured or quantified mean and diastolic brachial blood pressure: agreement with invasive records. [PDF]

Front Cardiovasc Med, 2023
Chemla D, Jozwiak M.
europepmc   +1 more source

ZER1 Restrains Pressure Overload‐Induced Cardiac Remodeling by Targeting DVL2 for Gly/N‐Degron‐Dependent Degradation

Advanced Science, EarlyView.
Pressure overload suppresses cardiomyocyte ZER1, weakening CRL2Zer1‐mediated DVL2 degradation and allowing DVL2 accumulation. Elevated DVL2 activates CaMKII‐HDAC4‐MEF2C signaling, drives fetal gene reactivation, and promotes pathological remodeling.
Mingchao Jiang, Zhehao Lin, Lu Chen, Ying Ni, Jun Zhou, Wenjuan Zhang, Huilin Wang, Peifeng Ying, Xiu Lu, Kai Wang, Qingran Kong, Naxin Xu, Dingsheng Zhao, Jianwei Li, Guohui Zhong, Xingchen Meng, Sarkawt Hamad, Junmeng Zheng, Yuan Fu, Rongjiang Qin, Xuran Chu, Shangxuan Li, Youyou Li, Yili Wu, Yi Wang, Weihong Song, Yingxian Li, Shukuan Ling   +27 more
wiley   +1 more source

Comparison of Central Aortic Pressure between Women with Preeclampsia and Normotensive Postpartum Women from an Urban Region of Western Mexico. [PDF]

Medicina (Kaunas), 2023
Hernández-Mora FJ, Cerda-Guerrero CK, García-Benavides L, Cervantes-Pérez E, Ramírez-Ochoa S, Vázquez-Beltrán JC, Cervantes-Guevara G, Ledezma-Hurtado E, Nápoles-Echauri A, González-Ojeda A, Fuentes-Orozco C, Hernández-Rivas MI, Chávez-Tostado M, Cervantes-Cardona GA.   +13 more
europepmc   +1 more source

Lymph Node Metastasis Pattern and Influencing Factors in Esophageal Squamous Cell Carcinoma

AGING MEDICINE, EarlyView.
Among 388 patients with esophageal squamous cell carcinoma who underwent curative resection, 144 (37.1%) developed lymph node metastasis. Upper thoracic tumors mainly involved upper mediastinal and upper right paratracheal nodes, whereas lower thoracic tumors more often involved paracardial and abdominal nodes.
Yuheng Wang, Qingqing Ding, Lei Xue, Jinhua Luo   +3 more
wiley   +1 more source

Central Aortic Pressure and Arterial Stiffness in Parkinson's Disease: A Comparative Study. [PDF]

Parkinsons Dis, 2022
Balal M, Demirkiran M, Paydas S.
europepmc   +1 more source

Design, Control, and Clinical Applications of Magnetic Actuation Systems: Challenges and Opportunities

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
This review aims to provide a broad understanding for interdisciplinary researchers in engineering and clinical applications. It addresses the development and control of magnetic actuation systems (MASs) in clinical surgeries and their revolutionary effects in multiple clinical applications.
Yingxin Huo, Lidong Yang, Tiantian Xu, Dong Sun   +3 more
wiley   +1 more source

Wave reflection quantification analysis and personalized flow wave estimation based on the central aortic pressure waveform. [PDF]

Front Physiol, 2023
Sun H, Yao Y, Liu W, Zhou S, Du S, Tan J, Yu Y, Xu L, Avolio A.   +8 more
europepmc   +1 more source

A Steerable and Expandable Magnetic Aspiration Catheter for Enhanced Aspiration Thrombectomy

Advanced Intelligent Systems, EarlyView.
This article presents a novel magnetic aspiration catheter (MAC) that can be both actively steered and undergo distal‐end expansion via externally applied magnetic fields. The MAC facilitates precise branch selection and enhances clot engagement by improving endovascular navigation and aspiration efficiency. Phantom experiments validate its feasibility
Hakjoon Lee, Xiao Dong, Dong‐in Kim, A. M. Masum Bulbul Chowdhury, Nader Latifi Gharamaleki, Jin‐young Kim, Sung Won Youn, Hongsoo Choi   +7 more
wiley   +1 more source