Results 251 to 260 of about 2,099,299 (308)

F‐Box and Leucine‐Rich Repeat Protein 4 (FBXL4) Maintains Sarcomere Integrity and Cardiac Function by Enhancing K48‐Linked Ubiquitinated Degradation of Profilin‐1 (PFN1)

open access: yesAdvanced Science, EarlyView.
Schematic diagram depicting the proposed signaling mechanisms underlying the effects of FBXL4 in the setting of cardiac hypertrophy. Under hypertrophic stimulation, cardiomyocytes‐specific overexpression FBXL4 maintains sarcomere integrity and cardiac function by enhancing K48‐linked ubiquitinated degradation of PFN1 at the K70 site.
Xingda Li   +11 more
wiley   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

open access: yesAdvanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang   +10 more
wiley   +1 more source

Digital assets: risks, regulations, mitigation. [PDF]

open access: yesFinanc Innov
Teng HW   +30 more
europepmc   +1 more source

Corrigendum: Navigating Through Innovation in Elderly's Health: A Scoping Review of Digital Health Interventions. [PDF]

open access: yesPublic Health Rev
Hirmas-Adauy M   +13 more
europepmc   +1 more source

The global macroeconomic burden of diabetes mellitus. [PDF]

open access: yesNat Med
Chen S   +9 more
europepmc   +1 more source

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