Results 41 to 50 of about 2,099,299 (308)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Transmission mechanisms in HANK: An application to Chile

Latin American Journal of Central Banking
Households in emerging economies are subject to significant income risk and have low access to financial markets. Leveraging multiple administrative microdata sources, this paper documents significant heterogeneity in asset holdings, income, and income ...
Benjamín García, Mario Giarda, Carlos Lizama, Ignacio Rojas   +3 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Bioinformatics analysis of HBV s gene mutation in blood donor

Zhongguo shuxue zazhi
Objective To analyze the infectious indicators, HBV s gene mutations and changes in bioinformatics characteristics of HBV DNA+ /HBsAg- blood donor. Methods A sample of HBV DNA+ /HBsAg- was screened by PCR method, and HBsAg/HBsAb/HBeAg/HBeAb/HBcAb of HBV ...
Jiacheng FAN, Qing LI, Xiuli CHEN, Shixiang LIU, Ye CHEN   +4 more
doaj   +1 more source

Exposures to climate change's physical risks in Chile

Latin American Journal of Central Banking, 2023
We estimate real estate’s exposure in Chile to five weather risks, including labor productivity loss due to heat, fires, floods, drought coastal deterioration as measured by the Chilean Climatic Risk Atlas (ARCLIM) and Climate Impact Explorer (CIE ...
Magdalena Cortina, Carlos Madeira
doaj   +1 more source

The European Central Bank [PDF]

, 2006
The establishment of the ECB and with it the launch of the euro has arguably been a unique endeavor in economic history, representing an important experiment in central banking.
Binder, Michael, Wieland, Volker
core  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Inflation and stock return volatility in selected African countries: A GARCH-MIDAS approach

Scientific African
Amidst persistent inflationary pressures in Africa and central banks raising rates to counter inflation, leading to a shift from stocks to alternative assets and impacting stock return volatility, this paper investigates the influence of inflation on ...
Kamaludeen Muhammad, Abulbashar Saleh, Umar M. Bello, Jeremiah M. Tule, Elijah A. John, Joy E. Edet, Iheanacho Ohiaeri, Chukwuemeka N. Eneanya   +7 more
doaj   +1 more source

Characterization of the Chilean financial cycle, early warning indicators and implications for macro-prudential policies

Latin American Journal of Central Banking, 2021
From the perspective of an emerging country – Chile – we analyze the recommendations of the Basel Committee of Banking Supervision (BCBS) regarding the design and implementation of indicators to guide countercyclical capital buffer (CCyB) policy ...
Juan Francisco Martínez, Daniel Oda
doaj   +1 more source