Results 51 to 60 of about 2,099,299 (308)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Deposit interest rate pass-through in Central and Eastern European countries before and after 2021

Central Bank Review
The study analyzes interest rate pass-through for household and corporate deposits in specific markets in the Central and Eastern European (CEE) region, with a focus on the tightening cycle that began in mid-2021. This period is of particular interest to
Gábor Hajnal, Bálint Dancsik, Zsuzsanna Hosszú, Ákos Attila Ozoróczy   +3 more
doaj   +1 more source

The Euro Area in Between Crises? Considerations on Fiscal Policies and Rules

Intereconomics, 2022
Credibility of the revised fiscal rules will be crucial so that vulnerable countries can benefit from confidence effects. National ownership will be key in that respect and can be supported via a stronger role of independent national fiscal institutions.
Cristina Checherita-Westphal, Sebastian Hauptmeier, Nadine Leiner-Killinger   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Construction of blood quality monitoring indicator system in blood banks of Shandong

Zhongguo shuxue zazhi
Objective To establish a blood quality monitoring indicator system, in order to continuously improve blood quality and standardized management. Methods Based on the research of literature and standards, and guided by the key control points of blood ...
Qun LIU, Xuemei LI, Yuqing WU, Zhiquan RONG, Zhongsi YANG, Zhe SONG, Shuhong ZHAO, Lin ZHU, Shuli SUN, Wei ZHANG, Jinyu HAN, Xiaojuan FAN, Hui YE, Mingming QIAO, Hua SHEN, Dunzhu GONGJUE, Yunlong ZHUANG   +16 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

A diffusion index analysis of the Argentinean business economic cycle based on the “Survey of Business Economic Perspectives”

Latin American Journal of Central Banking
The Central Banks use diffusion indexes (DIs) to synthesize information from proprietary surveys that complement official statistics generating real-time proxies of the economically relevant variables.
Pedro Elosegui, Mirta González, María Cecilia Pérez, Máximo Sangiácomo   +3 more
doaj   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

An extended Taylor rule for a small open African economy

Scientific African
This paper estimated a monetary policy rule for Nigeria by augmenting the traditional Taylor rule model, using data spanning 2010Q1 to 2023Q2 in a Dynamic Ordinary Least Square regression.
Omolara Omotunde Duke, Dominic Opiah, Obioma Asuzu, Seyi Saint Akadiri, Aminu Umaru, Peter Offum, Abubakar Sani Ibrahim   +6 more
doaj   +1 more source