Results 91 to 100 of about 9,120,288 (390)

Diet and Mobility in the Corded Ware of Central Europe

open access: yesPLoS ONE, 2016
Isotopic investigations of two cemetery populations from the Corded Ware Culture in southern Germany reveal new information on the dating of these graves, human diet during this period, and individual mobility. Corded Ware Culture was present across much
K. Sjögren, T. Price, K. Kristiansen
semanticscholar   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

‘Forebears’, ‘saints’ and ‘martyrs’: the politics of commemoration in Bulgaria in the 1880s and 1890s [PDF]

open access: yes, 2008
Book description: The relationship between states, societies, and individuals in Central and Eastern Europe has been characterised by periods of change and redefinition.
Detchev, S.
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Bourbon Ceremony on the Former Habsburg Territory

open access: yesCentral Europe, 2022
This article examines descriptions of the wedding ceremony of Habsburg Archduchess Maria Amalia and Duke Ferdinand of Parma in 1769 and specifically analyzes the decision-making behind her marriage and the symbolism replete in her wedding ceremony ...
Mike Zhou
doaj  

Appendices [PDF]

open access: yes, 2017
Although there has been vivid academic debate as to what extent Sovereign Wealth Funds (SWFs) are motivated by political reasons, it is rather clear that countries can use state-owned investment funds as a tool of their foreign policy. Even Barack Obama,

core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

The Jagiellonian Genesis Tapestries (1553)

open access: yesCentral Europe, 2022
This website explores the Jagiellonian Genesis Tapestries from 1553. It provides an overview of their commission and history and also provides an analysis of the tapestries and the symbolism within them.
Anne Stackpole
doaj  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Home - About - Disclaimer - Privacy