Results 61 to 70 of about 7,950,860 (300)
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Europeanization, Enlargement and Social Policy in Central and Eastern Europe [PDF]
This paper aims at exploring the relationship between Europeanization, Enlargement andsocial policy developments in Central and Eastern Europe. In particular, it examines theimportance of ideas, interests and institutions in the making of contemporary ...
Alfio Cerami
core
Shared Prosperity: Paving the Way in Europe and Central Asia
, 2014 The World Bank has recently defined two strategic goals: ending extreme poverty and boosting shared prosperity. Shared prosperity is measured as income growth among the bottom 40 percent of the income distribution in the population.
Maurizio Bussolo +3 more
core +1 more source
Central Europe, 2021 In 1885, German Chancellor Otto von Bismarck ordered the expulsion of over 30,000 non-naturalized Poles and Jews from Germany’s Prussian provinces. This article explores Bismarck’s strategic aims behind his decision to authorize one of the most extreme ...
Sam Hall
doaj
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Central's first homecoming; male students standing on street in single file line
, 1920 In Central Methodist University (formerly Central College)'s first homecoming parade, male students in costume stand in single file on an unpaved road in Fayette ...
Central Methodist University, Smiley Memorial Library
core +1 more source
Europe in Movement: Migration from and into Eastern and Central Europe
Revista CIDOB d'Afers Internacionals, 2008 Two historical events have had a fundamental importance in shaping the new migration trends in Eastern and Central Europe (ECE): the collapse of the Soviet block and the region’s return to Europe, when the first eight countries became full members of the
Marek Okólski
doaj