Results 21 to 30 of about 50,114 (246)

Measurement of Serum Free Thyroxine Index May Provide Additional Case Detection Compared to Free Thyroxine in the Diagnosis of Central Hypothyroidism

Case Reports in Endocrinology, 2015
The diagnosis of central hypothyroidism is often suspected in patients with hypothalamic/pituitary pathology, in the setting of low, normal, or even slightly elevated serum TSH and low free thyroxine (FT4). We present four cases of central hypothyroidism
Kevin M. Pantalone, Betul Hatipoglu, Manjula K. Gupta, Laurence Kennedy, Amir H. Hamrahian   +4 more
doaj   +1 more source

Features of the nervous system lesion in primary hypothyroidism (literature review)

Mìžnarodnij Endokrinologìčnij Žurnal, 2018
The review presents the pathogenetic mechanisms of central and peripheral nervous system pathology in primary hypothyroidism. Lack of thyroid hormones leads to changes in the organization of the central nervous system, decrease in the energy supply of ...
I.I. Bilous, L.B. Pavlovych
doaj   +1 more source

Oxidative DNA damage and subclinical hypothyroidism in children with obesity

Egyptian Pediatric Association Gazette, 2021
Background Obesity-related oxidation stress plays a key role in obesity complications; however, its relation to thyroid status is an area for further research.
Inass Hassan Ahmad, Marwa khairy Abd Elwahab, Mervat El Shahat El Wakeel, Mohamed A. M. Kamal, Marwa Elhady   +4 more
doaj   +1 more source

Wolcott Rallison Syndrome: Beyond Neonatal Diabetes

Indian Pediatrics Case Reports, 2022
Background: Wolcott–Rallison Syndrome (WRS) is a rare autosomal recessive disorder characterized by permanent neonatal diabetes mellitus, skeletal dysplasia, hepatic dysfunction, and other systemic associations. Clinical Description: A 3-month-old infant
Medha Mittal, Shankar Dhungel, Harini Bandarpalli, Anuradha Rai   +3 more
doaj   +1 more source

Congenital Central Hypothyroidism due to a Homozygous Mutation in the TSHβ Subunit Gene

Case Reports in Pediatrics, 2011
Congenital central hypothyroidism (CCH) is a rare condition occurring in 1 : 20000 to 1 : 50000 newborns. As TSH plasma levels are low, CCH is usually not detected by TSH-based neonatal screening for hypothyroidism, and, as a result, diagnosis is often ...
Sarah Catharina Grünert, Miriam Schmidts, Joachim Pohlenz, Matthias Volkmar Kopp, Markus Uhl, Karl Otfried Schwab   +5 more
doaj   +1 more source

Screening for Mutations in Isolated Central Hypothyroidism Reveals a Novel Mutation in Insulin Receptor Substrate 4

Frontiers in Endocrinology, 2021
BackgroundCentral hypothyroidism (CeH) is a rare condition affecting approximately 1:16 000- 100 000 individuals. Congenital forms can harm normal development if not detected and treated promptly.
Konrad Patyra, Konrad Patyra, Kristiina Makkonen, Kristiina Makkonen, Maria Haanpää, Maria Haanpää, Sinikka Karppinen, Liisa Viikari, Jorma Toppari, Jorma Toppari, Jorma Toppari, Mary Pat Reeve, Jukka Kero, Jukka Kero, Jukka Kero   +14 more
doaj   +1 more source

Pituitary function after transsphenoidal surgery including measurement of basal morning cortisol as predictor of adrenal insufficiency

Endocrine Connections, 2021
Introduction: Patients with pituitary adenomas undergoing transsphenoidal surgery require pre- and post-surgery examination of pituitary hormones. There is currently no consensus on how to evaluate the adrenal axis post-surgery.
Ida Staby, Jesper Krogh, Marianne Klose, Jonas Baekdal, Ulla Feldt-Rasmussen, Lars Poulsgaard, Jacob Bertram Springborg, Mikkel Andreassen   +7 more
doaj   +1 more source

Central Hypothyroidism in Severe Sepsis [PDF]

Acta Endocrinologica (Bucharest), 2019
A partial or complete deficiency of hormone secretion by pituitary gland (hypopituitarism) is commonly seen after a pituitary apoplexy caused by an infarction of a pituitary adenoma or pituitary hyperplasia (as in Sheehan's syndrome). Hypopituitarism may also follow surgery, when hypovolemia, anticoagulation, fat/air/bone marrow microemboli can provoke
S N, Benea, M, Lazar, A, Hristea, R M, Hrisca, C M, Niculae, R V, Moroti   +5 more
openaire   +2 more sources

Central TSH Dysregulation in a Patient with Familial Non-Autoimmune Autosomal Dominant Hyperthyroidism Due to a Novel Thyroid-Stimulating Hormone Receptor Disease-Causing Variant

Medicina, 2021
Background and Objectives. Familial non-autoimmune autosomal dominant hyperthyroidism (FNAH) is a rare cause of childhood hyperthyroidism. It is caused by the thyroid-stimulating hormone receptor (TSHR) gene variants. So far, only around 40 families with
Jasna Suput Omladic, Maja Pajek, Urh Groselj, Katarina Trebusak Podkrajsek, Magdalena Avbelj Stefanija, Mojca Zerjav Tansek, Primoz Kotnik, Tadej Battelino, Darja Smigoc Schweiger   +8 more
doaj   +1 more source

Phase Ib study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis

Hepatology, EarlyView., 2022
Phase 1b study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis. Abstract Background and Aims We evaluated the efficacy and safety of the antiangiogenic tyrosine kinase inhibitor anlotinib plus TQB2450, a programmed death‐ligand 1 inhibitor in pretreated advanced biliary tract cancers (BTCs ...
Jun Zhou, Yongkun Sun, Wen Zhang, Jiajia Yuan, Zhi Peng, Wei Wang, Jifang Gong, Lin Yang, Yanshuo Cao, Hong Zhao, Chao Chen, Weifeng Wang, Lin Shen, Aiping Zhou   +13 more
wiley   +1 more source