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Indian Journal of Endocrinology and Metabolism, 2011 Central hypothyroidism is defined as hypothyroidism due to insufficient stimulation by thyroid stimulating hormone (TSH) of an otherwise normal thyroid gland. It has an estimated prevalence of approximately 1 in 80,000 to 1 in 120,000.
Vishal Gupta, Marilyn Lee
doaj +6 more sources
A Case of Congenital Central Hypothyroidism Caused by a Novel Variant (Gln1255Ter) in IGSF1 Gene [PDF]
JCRPE, 2021 Loss-of-function mutations in the immunoglobulin superfamily, member 1 (IGSF1) gene cause X-linked central hypothyroidism, and therefore its mutation affects mainly males.
Doğa Türkkahraman +2 more
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Central Hypothyroidism in Miniature Schnauzers [PDF]
Journal of Veterinary Internal Medicine, 2016 Abstract Background Primary hypothyroidism is a common endocrinopathy in dogs. In contrast, central hypothyroidism is rare in this species. Objectives The objective of this article is to describe the occurrence and ...
Voorbij, Annemarie MWY +4 more
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Pituitary, 2008 Central hypothyroidism (CH) is a rare cause of hypothyroidism due to an insufficient stimulation of an otherwise normal thyroid gland and it is caused by either pituitary (secondary hypothyroidism) or hypothalamic (tertiary hypothyroidism) defects.
Andrea, Lania +2 more
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Less known aspects of central hypothyroidism: Part 2 – Congenital etiologies [PDF]
Journal of Clinical & Translational Endocrinology, 2018 Central hypothyroidism (CH) occurs approximately in 1:50,000, and therefore is expected to be one thousand times rarer compared with primary hypothyroidism.
Salvatore Benvenga +3 more
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Less known aspects of central hypothyroidism: Part 1 – Acquired etiologies [PDF]
Journal of Clinical & Translational Endocrinology, 2018 Central hypothyroidism (CH) is a rare cause of hypothyroidism. CH is frequently overlooked, as its clinical picture is subtle and includes non-specific symptoms; furthermore, if measurement of TSH alone is used to screen for thyroid function, TSH ...
Salvatore Benvenga +3 more
doaj +2 more sources
Congenital nystagmus and central hypothyroidism
International Journal of Pediatric Endocrinology, 2015 We observed a male newborn with bilateral nystagmus and central hypothyroidism without hypoprolactinemia due to a deletion of chromosome band Xq26.1q26.2, containing FRMD7 and IGSF1. These two loss-of function mutations are known to cause, respectively, congenital nystagmus and the ensemble of central hypothyroidism, hypoprolactinemia and testicular ...
Reynaert, Nele +2 more
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Congenital Central Hypothyroidism due to a Homozygous Mutation in the TSHβ Subunit Gene [PDF]
Case Reports in Pediatrics, 2011 Congenital central hypothyroidism (CCH) is a rare condition occurring in 1 : 20000 to 1 : 50000 newborns. As TSH plasma levels are low, CCH is usually not detected by TSH-based neonatal screening for hypothyroidism, and, as a result, diagnosis is often ...
Sarah Catharina Grünert +5 more
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Recent advances in central congenital hypothyroidism [PDF]
Journal of Endocrinology, 2015 Central congenital hypothyroidism (CCH) may occur in isolation, or more frequently in combination with additional pituitary hormone deficits with or without associated extrapituitary abnormalities. Although uncommon, it may be more prevalent than previously thought, affecting up to 1:16 000 neonates in the Netherlands. Since TSH is
Schoenmakers, Nadia +3 more
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Central hypothyroidism: are patients undertreated? [PDF]
Eur Thyroid J, 2022 Introduction Thyroid hormone replacement in central hypothyroidism (CHT) is more difficult than in primary hypothyroidism (PHT), putting patients at risk for inappropriate substitution. In this study, we compared the dosage of thyroid hormone replacement in patients with CHT with that of patients with PHT.
Marlier J +3 more
europepmc +3 more sources