Results 91 to 100 of about 481,762 (313)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Is the red-legged partridge Alectoris rufa naturally colonising the north of Lazio region, Italy?

open access: yesAvocetta, 2013
The present study aimed to update the distribution of the red-legged partridge Alectoris rufa in Central Italy, with particular reference to the northern Lazio Region.
Riccardo Primi   +4 more
doaj   +1 more source

Paleoseismological surveys for the identification of capable faults in urban areas: the case of the Mt. Marine Fault (Central Apennines, Italy).

open access: yes, 2022
In order to constrain the Fault Displacement Hazard (FDH) of the town of Pizzoli, located 10 km NW of L’Aquila (Central Apennines, Italy), we performed two paleoseismological trenches across multiple fault splays within the hanging wall of the main Mt ...
Chiappini, Massimo   +16 more
core   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim   +4 more
wiley   +1 more source

Paleoseismology of silent faults in the Central Apennines (Italy): the Campo Imperatore Fault (Gran Sasso Range Fault System)

open access: yesAnnals of Geophysics, 2003
Paleoseismological analyses were performed along the Campo Imperatore Fault (part of the Gran Sasso Range Fault System) in order to define the seismogenic behaviour (recurrence interval for surface faulting events, elapsed time since the last ...
M. Moro, P. Galli, F. Galadini
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

open access: yesFEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas   +6 more
wiley   +1 more source

Paleoseismology of silent faults in the Central Apennines (Italy): the Mt. Vettore and Laga Mts. Faults

open access: yesAnnals of Geophysics, 2003
Paleoseismological analyses have been performed in the Central Apennines along faults showing geomorphological evidence of Late Quaternary activity and characterised by the absence of historical seismicity. Three trenches were made along the Mt.
P. Galli, F. Galadini
doaj   +1 more source

Rock properties of the upper-crust in Central Apennines (Italy) derived from high-resolution 3-D tomography

open access: yes, 2003
High-resolution 3-D P and S-wave velocity models of a central sector of the Apennines (Central Italy) are computed by inverting first arrival times from an aftershock sequence (September–December, 1997) following the Mw 5.7 and Mw 6.0 Umbria-Marche ...
Favali, P.   +3 more
core   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito   +14 more
wiley   +1 more source

Hygropetric and litter-inhabiting spiders (Araneae) from the Abruzzo Apennines (Central Italy) [PDF]

open access: yes, 2009
We present the results of a study of spider material extracted by means of Berlese apparatus from wet mosses and by litter sieving in broadleaf woods within several natural reserves of the Abruzzo region (Central Italy).
Pannunzio, Giovanna   +6 more
core   +1 more source

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