Results 51 to 60 of about 1,738,719 (304)
Large mammal remains from the early pleistocene site of Podere San Lorenzo (Perugia, Central Italy) [PDF]
, 2019 Most of the research on fossil mammals from Umbria (central Italy) has been carried out in the southwestern branch of the Tiber basin, due to its paleontological richness.
Azzarà, Beatrice +6 more
core +3 more sources
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
MEASURING GRAVITOMAGNETIC EFFECTS BY MEANS OF RING LASERS [PDF]
, 2013 Light is a good probe for general relativistic effects. Exploiting the asymmetry of the propagation in the vicinity of a central rotating mass it is possible to use a ring laser in order to measure the frame dragging of the reference frames by the ...
Lense J., Thirring H.
core +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
A new species of Aleurolobus Quaintance et Baker (Homoptera, Aleyrodidae) from Southern Europe. [PDF]
, 1996 Aleurolobus teucrii n. sp. is described from southern Italy and the Maltese Islands (Central Mediterranean). The species seems to be monophagous on Teucrium fruticans L. A key to the European species of this genus (A.
Mifsud, David, Palmeri, Vincenzo
core
QUATERNARY HISTORY OF FAG US IN THE ITALIAN PENINSULA [PDF]
, 1998 The Upper Pleistocene and Holocene history of the genus Fagus in Italy is reviewed. Fagus was present in central Italy during the last interglacial (Eemian), when it was virtually absent from the rest of Europe, markedly expanded in the following forest ...
D. MAGRI
core +3 more sources
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece +18 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Planning seismic inner areas in Central Italy
TeMA: Journal of Land Use, Mobility and Environment, 2022 Natural calamities that repeatedly hit the Country, ranging from earthquake to climate change induced events – like landslides and floods – resulted in huge damages, worsened by the infrastructural degrade and by the abandonment of some territories ...
Giovanni Marinelli +3 more
doaj +1 more source