Results 81 to 90 of about 17,919,985 (298)

Nosocomial infections among COVID-19 patients: an analysis of intensive care unit surveillance data

Antimicrobial Resistance and Infection Control, 2021
Surveillance of nosocomial infections, like catheter-associated urinary tract infection (CAUTI), central line-associated bloodstream infection, possible ventilator-associated pneumonia and secondary bloodstream infections were observed to study the ...
Clara Chong Hui Ong, Sharifah Farhanah, Kyaw Zaw Linn, Ying Wei Tang, Chu Ying Poon, Allie Yin Lim, Hui Ru Tan, Nur Hafizah Binte Hamed, Xiaowei Huan, Ser Hon Puah, Benjamin C. H. Ho, Margaret M. L. Soon, Brenda S. P. Ang, Shawn Vasoo, Monica Chan, Yee Sin Leo, Oon Tek Ng, Kalisvar Marimuthu   +17 more
doaj   +1 more source

Structural Basis of Shiga Toxin Neutralization by Human Antibodies Targeting Canonical Receptor‐Binding and Non‐Canonical Assembly Sites

Advanced Science, EarlyView.
Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Jianting Ke, Xin Li, Xiaoli Wang, Zhaoxia Huang, Shaojie Xue, Yuyang Liu, Jing Pan, Guowei Hu, Yayu Wang, Cheng Wang, Shoudeng Chen   +10 more
wiley   +1 more source

A systematic review of central-line-associated bloodstream infection (CLABSI) diagnostic reliability and error

, 2019
Objective:To establish the reliability of the application of National Health and Safety Network (NHSN) central-line-associated bloodstream infection (CLABSI) criteria within established reporting systems internationally.Design:Diagnostic-test accuracy ...
Marsh, Nicole, Larsen, Emily N., Larsen, Emily N, Gavin, Nicole, Runnegar, Naomi, Rickard, Claire M, Webster, Joan, Rickard, Claire M.   +7 more
core   +1 more source

Integrated O2 and H2 Gas Therapy via Microneedle‐Assisted Photocatalytic Water Splitting for Accelerating Diabetic Full‐Thickness Skin Wound Healing

Advanced Science, EarlyView.
A concept of integrated O2 and H2 gas therapy is achieved using a gas‐producing material. PMP nanoparticles, fabricated from platinum, MIL‐101(Fe)‐NH2, and phosphotungstic acid, are integrated into bilayer gelatin methacryloyl microneedles for transdermal delivery. These microneedles enable integrated O2 and H2 gas therapy and promote wound healing via
Zesheng Chen, Yanchao Yu, Xingyuan Xiao, Wenwen Cheng, Ye Yang, Zhengyao Zhang, Wang Wang, Zhijun Zhou, Weikang Hu, Xiaolong Wang, Bing Li, Kwang Leong Choy, Yun Chen, Zijian Wang   +13 more
wiley   +1 more source

Effect of catheter dwell time on the risk of central line-associated bloodstream infections in central venous catheters and peripherally inserted central catheters

Antimicrobial Resistance and Infection Control
Background Understanding the impact of catheter dwell time on the risk of central-line associated bloodstream infections (CLABSIs) is crucial to developing effective infection prevention strategies.
Vassiliki Pitiriga, Elsa Campos, John Bakalis, Konstantinos Sagris, George Georgiadis, George Saroglou, Athanasios Tsakris   +6 more
doaj   +1 more source

Nosocomial infection in a pediatric intensive care unit in a developing country

Brazilian Journal of Infectious Diseases
OBJECTIVE: Determine the rate and outcome of nosocomial infection (NI) in pediatric intensive care unit patients in a developing country. DESIGN: Prospective cohort study using the Centers for Disease Control and Prevention definitions to diagnose ...
Marcelo L. Abramczyk, Werther B. Carvalho, Eduardo S. Carvalho, Eduardo A. S. Medeiros   +3 more
doaj   +1 more source

The association between hospital characteristics and incidence rates of central line-associated bloodstream infection in California community hospitals.

, 2022
The association between hospital characteristics and incidence rates of central line-associated bloodstream infection in California community hospitals.
Garry Huang (13889425), Chia-Hui Wang (91448), Ella Calixta Nelson (13889422), Nai-Wen Kuo (13889428)   +3 more
core   +1 more source

A Dual‐Membrane Biomimetic Nanoplatform Enables Triple‐Modal Therapy Against SARS‐CoV‐2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi

Advanced Science, EarlyView.
[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Hui Li, Bohan Zhang, Chao Shang, Yi Li, Te Zhao, Shengya Liu, Dan Liu, Junwei Che, Cuiling Zhang, Pinghui Wu, Wenjie Yang, Junjie Ding, Yuhua Ran, Yanan Zhai, Haihua Xiao, Jing Gao, Xiao Li, Chunsheng Gao, Lin Li, Zhiping Li   +19 more
wiley   +1 more source

Effect of Central Line Maintenance Bundle on Its Associated Blood Stream Infections among Oncology Patients [PDF]

Egyptian Journal of Health Care
Background: One essential strategy for preventing bloodstream infections linked to central lines is using of care bundles for the insertion and upkeep of central venous catheters.
Marwa Ali Almasry Abd Alsalam, Eman Fadl Abd Elkhalik, Sahar Hamza Taha, Lobna Mohammed Gamal Ali   +3 more
doaj   +1 more source

Ribonucleotides Amplify Mitochondrial DNA‐Driven cGAS–STING Activation via FdUMP‐ribonucleotide Hybrid Particles to Potentiate Chemoimmunotherapy

Advanced Science, EarlyView.
This work develops a metabolic sharing strategy that employs cytidine monophosphate (CMP) to competitively reprogram floxuridine (FUDR) pyrimidine metabolism in colorectal tumor cells. Elevated intracellular FdUMP induces nucleotide imbalance, drives mitochondrial DNA release and cGAS‐STING innate immune cascade activation, and potentiates robust ...
Chao Wang, Chenxuan Zhao, Yesong Yao, Zhiwen Zou, Anxin Shi, Zhuo Feng, Mingkang Yang, Yue Yu, Yang Liu, Xuehui Rui, Jinhui Wu   +10 more
wiley   +1 more source