Results 61 to 70 of about 17,919,985 (298)

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Patterns and outcomes of health-care associated infections in the medical wards at Bugando medical centre: a longitudinal cohort study

Antimicrobial Resistance and Infection Control, 2023
Background The burden of healthcare associated infections (HCAIs) in low- and middle-income countries (LMICs) remains underestimated due to diagnostic complexity and lack of quality surveillance systems.
Maliha I. Kassam, Vitus Silago, Prisca Damiano, Bahati Wajanga, Jeremiah Seni, Stephen E. Mshana, Samuel Kalluvya   +6 more
doaj   +1 more source

Data Analytics for Diagnosis and Prediction of Central Line-Associated Bloodstream Infections in Critical Care Units

, 2022
Central line-associated bloodstream infections are among the leading causes of in-hospital deaths in the United States and are a significant factor for increased morbidity, mortality, and healthcare costs.
Moghaddas, Ramin, Hooshmand, Mary A, Toledo, Christine Susana, Skordilis, Erotokritos   +3 more
core   +1 more source

Gonadotropin‐Inhibitory Hormone (GnIH) and Its Receptor GPR147 Mediates Acute Stress‐Induced Activation of the Locus Coeruleus‐SAM Axis

Advanced Science, EarlyView.
ABSTRACT Gonadotropin‐inhibitory hormone (GnIH, also known as RFamide‐related peptide‐3, RFRP‐3) is a hypothalamic neuropeptide that regulates vertebrate reproduction via its receptor GPR147. Although GnIH is known to mediate stress‐induced reproductive suppression, its role in broader stress responses remains unclear.
Jiani Zhang, Hongyu Zhu, Wenqi Wang, Bingqian Shen, Yuanyuan Xin, Xingxing Song, Xuanyi Lu, Lixuan Li, Siting Chen, Xiaochen Zhang, Jialing Zeng, Haodong Zheng, Jianlong Lao, Ke Peng, Yixian Wei, Jiaming Zheng, Chuanhuo Hu, Xiaoye Wang, Xun Li   +18 more
wiley   +1 more source

Epidemiology of community-onset bloodstream infections in Bouaké, central Côte d'Ivoire [PDF]

, 2015
Bacterial bloodstream infections (BSI) account for considerable morbidity worldwide, but epidemiological data from resource-constrained tropical settings are scarce.
Plo, J.K., F.S. Touré, Yenan, P.J., M. Herrmann, H. Tia, I.I. Bogoch, Akoua-Koffi, C., Yao, C., Yenan, P. J., P. Monemo, J. Utzinger, Plo, J. K., Cissé, A., J.K. Plo, C. Yao, S.L. Becker, Becker, S. L., Touré, F. S., Tia, H., Monemo, P., Ilupeju, V., Utzinger, J., Becker, S.L., Bogoch, I. I., C. Akoua-Koffi, P.J. Yenan, Herrmann, M., A. Cissé, Touré, F.S., Bogoch, I.I., V. Ilupeju   +30 more
core   +1 more source

Risk factors for central venous catheter-related bloodstream infection in oncology patients: an integrative review

, 2022
The aim of this integrative review was to identify scientific studies on risk factors for bloodstream infections associated with central venous catheters (CVC) in cancer patients. The research question was formulated according to the PICO framework.
Fábio Wildson Gurgel Costa, Francisco Samuel Carvalho, Antonio Neudimar Bastos Costa, Elaine Cristina Bezerra Bastos, Filipe Nobre Chaves, Camila Melo Mesquita, Maria Raquel Raquel R. Carvalho   +6 more
core   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Jugular vs femoral vein for central venous catheterization in pediatric cardiac surgery (PRECiSE): study protocol for a randomized controlled trial

Trials, 2018
Background Placement of central venous catheters (CVCs) is essential and routine practice in the management of children with congenital heart disease. The purpose of the present protocol is to evaluate the risk for infectious complications in terms of ...
Simona Silvetti, Tommaso Aloisio, Anna Cazzaniga, Marco Ranucci   +3 more
doaj   +1 more source

Hospital-acquired, laboratory-confirmed bloodstream infection: increased hospital stay and direct costs. [PDF]

, 2002
OBJECTIVES: To determine increased hospital stay and direct costs attributable to hospital-acquired, laboratory-confirmed bloodstream infection (BSI), and to evaluate the matching variable length of stay (LOS).
NOAH N., Noah, Norman, Orsi, Giovanni Battista, DI STEFANO L., Di Stefano, Lidia   +4 more
core   +1 more source

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source