Results 101 to 110 of about 243,904 (249)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

PHENOTYPIC CHARACTERIZATION AND INTRACELLULAR CYTOKINES OF MEMORY T-CELLS IN MULTIPLE SCLEROSIS PATIENTS AFTER T-CELL VACCINATION

Acta Biomedica Scientifica, 2012
Multiple sclerosis (RS) patients were treated with a vaccine consisted of autological mielin-reactive T-cells. Effector memory CD8+ CD45RO+CD62L- T-cells as well as central memory CD4+ CD45RO+CD62L+ and CD8+ CD45RO+CD62L+ T-cells were significantly ...
I. P. Ivanova, I. V. Savkin, G. V. Seledtsova, A. A. Shishkov, V. I. Seledtsov   +4 more
doaj  

Efficacy and Safety of Central Memory T Cells Combined With Adjuvant Therapy to Prevent Recurrence of Hepatocellular Carcinoma With Microvascular Invasion: A Pilot Study. [PDF]

Front Oncol, 2021
Cai J, Zhao J, Liu D, Xie H, Qi H, Ma J, Sun Z, Zhao H.   +7 more
europepmc   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

GPA33 is expressed on multiple human blood cell types and distinguishes CD4⁺ central memory T cells with and without effector function. [PDF]

Eur J Immunol, 2021
Opstelten R, Suwandi JS, Slot MC, Morgana F, Scott AM, Laban S, Nikolic T, Turksma AW, Kroeze A, Voermans C, Zwaginga JJ, Roep BO, Amsen D.   +12 more
europepmc   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

Distribution and function of human long-lasting T cells in aging and non-small cell lung cancer

Frontiers in Immunology
T lymphocytes, essential components of the adaptive immune system, orchestrate pathogen-specific responses and long-term immunological memory through heterogeneous subsets with distinct functional properties and spatial distributions.
Jia Xuan Tan, Hua Run Yu, Yong Gu, Hai Hong   +3 more
doaj   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Activated/Cycling Treg Deficiency and Mitochondrial Alterations in Immunological Non-Responders to Antiretroviral Therapy

Frontiers in Bioscience-Landmark
Background: Regulatory T-cells (Tregs) play a crucial role in maintaining immune homeostasis, but their dynamics are altered in a subset of people living with Human Immunodeficiency Virus (HIV) known as immunological non-responders ...
Konstantin Shmagel, Evgeniya Saidakova, Larisa Korolevskaya, Violetta Vlasova, Souheil-Antoine Younes   +4 more
doaj   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source