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Epigenetic control of tissue resident memory T cells. [PDF]

Front Immunol
Tissue-resident memory T cells (TRM) represent a heterogeneous population of T cells that exhibit both effector and memory functionalities. They express specific gene signatures that enable them to occupy tissues without recirculating, thus providing a ...
Lan Z, Chen Z, Yang N, Liu T, Li S, Shi Y, Gu J.   +6 more
europepmc   +2 more sources

Tissue-Resident Memory T Cells in Cancer Metastasis Control. [PDF]

Cells
Tissue-resident memory T (TRM) cells have emerged as critical sentinels in the control of cancer metastasis, yet their precise roles across different tumor types and tissues remain underappreciated.
Montgomery TH, Master AP, Jin Z, Shi Q, Lai Q, Desai R, Zhang W, Maharjan CK, Kolb R.   +8 more
europepmc   +2 more sources

Tissue-resident memory T cells in urinary tract diseases. [PDF]

Front Immunol
Tissue-resident memory T (TRM) cells are a specialized subset of memory T cells that permanently reside in non-lymphoid tissues, providing localized and long-lasting immune protection.
Xu G, Li Y, Lu G, Xie D.
europepmc   +2 more sources

CXCR6 by increasing retention of memory CD8+ T cells in the ovarian tumor microenvironment promotes immunosurveillance and control of ovarian cancer

Journal for ImmunoTherapy of Cancer, 2021
Purpose Resident memory CD8 T cells, owing to their ability to reside and persist in peripheral tissues, impart adaptive sentinel activity and amplify local immune response, and have beneficial implications for tumor surveillance and control. The current
Wenjun He, Ravikumar Muthuswamy, Kunle Odunsi, Junko Matsuzaki, Sebastiano Battaglia, Anthony Miliotto, Thinle Chodon, Cheryl Eppolito, Protul Shrikant, AJ Robert McGray, Tsuji Takemasa, Richard Koya, Brian D Lichty   +12 more
doaj   +1 more source

Pathophysiology of Skin Resident Memory T Cells

Frontiers in Immunology, 2021
Tissue resident memory T (TRM) cells reside in peripheral, non-lymphoid tissues such as the skin, where they act as alarm-sensor cells or cytotoxic cells.
Yoshiki Tokura, Yoshiki Tokura, Pawit Phadungsaksawasdi, Kazuo Kurihara, Toshiharu Fujiyama, Tetsuya Honda   +5 more
doaj   +1 more source

Skin-resident CD4+ T cells protect against Leishmania major by recruiting and activating inflammatory monocytes. [PDF]

PLoS Pathogens, 2017
Tissue-resident memory T cells are required for establishing protective immunity against a variety of different pathogens, although the mechanisms mediating protection by CD4+ resident memory T cells are still being defined.
Nelson D Glennie, Susan W Volk, Phillip Scott   +2 more
doaj   +1 more source

T cell kinetics reveal expansion of distinct lung T cell subsets in acute versus in resolved influenza virus infection

Frontiers in Immunology, 2022
Influenza virus infection is restricted to airway-associated tissues and elicits both cellular and humoral responses ultimately resulting in generation of memory cells able to initiate a rapid immune response against re-infections.
Malin Eriksson, Malin Eriksson, Susanne Nylén, Kjell-Olov Grönvik   +3 more
doaj   +1 more source

Resident Memory T Cells in Autoimmune Skin Diseases

Frontiers in Immunology, 2021
Tissue resident memory T cells (TRM) are a critical component of the immune system, providing the body with an immediate and highly specific response against pathogens re-infecting peripheral tissues. More recently, however, it has been demonstrated that
Grace E. Ryan, John E. Harris, Jillian M. Richmond   +2 more
doaj   +1 more source

Tissue-resident memory T cells in gastrointestinal tumors: turning immune desert into immune oasis

Frontiers in Immunology, 2023
Tissue-resident memory T cells (Trm) are a particular type of T cell subgroup, which stably reside in tissues and have been revealed to be the most abundant memory T cell population in various tissues.
Mengjie Liang, Xingzhou Wang, Daming Cai, Wenxian Guan, Xiaofei Shen   +4 more
doaj   +1 more source

Interplay of Inflammatory, Antigen and Tissue-Derived Signals in the Development of Resident CD8 Memory T Cells

Frontiers in Immunology, 2021
CD8 positive, tissue resident memory T cells (TRM) are a specialized subset of CD8 memory T cells that surveil tissues and provide critical first-line protection against tumors and pathogen re-infection.
Curtis J. Pritzl, Mark A. Daniels, Emma Teixeiro   +2 more
doaj   +1 more source