Results 1 to 10 of about 70,024 (278)

Tissue‐resident memory T cells in diseases and therapeutic strategies [PDF]

MedComm
Tissue‐resident memory T (TRM) cells are crucial components of the immune system that provide rapid, localized responses to recurrent pathogens at mucosal and epithelial barriers. Unlike circulating memory T cells, TRM cells are located within peripheral
Daoyuan Xie, Guanting Lu, Gang Mai, Qiuyan Guo, Guofeng Xu   +4 more
doaj   +5 more sources

Epigenetic control of tissue resident memory T cells [PDF]

Frontiers in Immunology
Tissue-resident memory T cells (TRM) represent a heterogeneous population of T cells that exhibit both effector and memory functionalities. They express specific gene signatures that enable them to occupy tissues without recirculating, thus providing a ...
Zhiyi Lan, Zhiyi Lan, Zhiyi Lan, Zeyu Chen, Zeyu Chen, Nan Yang, Nan Yang, Tong Liu, Tong Liu, Siqi Li, Siqi Li, Yuling Shi, Yuling Shi, Jun Gu, Jun Gu   +14 more
doaj   +5 more sources

The Multifaceted Role of Tissue-Resident Memory T Cells.

Annual Review of Immunology
Regionalized immune surveillance relies on the concerted efforts of diverse memory T cell populations. Of these, tissue-resident memory T (TRM) cells are strategically positioned in barrier tissues, where they enable efficient frontline defense against ...
S. Christo, Simone L. Park, Scott N. Mueller, Laura K. Mackay   +3 more
semanticscholar   +5 more sources

Asynchronous aging and turnover of human circulating and tissue-resident memory T cells across sites. [PDF]

Immunity
SUMMARY Memory T cells are maintained in tissues as circulating effector-memory (TEM) and tissue-resident (TRM) populations for protective immunity, though the role of site and subset in memory persistence remains undefined.
Lam N, Angel JC, Buchholz BA, Lee Y, Weisberg SP, Brown BH, Davis-Porada J, Caron DP, Jensen IJ, Szabo PA, Ural BB, Wells SB, Kubota M, Matsumoto R, Brusko M, Brusko TM, Lu C, Yates AJ, Farber DL.   +18 more
europepmc   +4 more sources

Tissue-resident memory T cells populate the human brain [PDF]

Nature Communications, 2018
Tissue-resident immune cells are important for local protections from pathogens. Here the authors show that brain tissue-resident memory T cells (TRM cells) can be further subsetted by CD103 expression, with higher CD103 correlates with increased ...
Joost Smolders, Kirstin M. Heutinck, Nina L. Fransen, Ester B. M. Remmerswaal, Pleun Hombrink, Ineke J. M. ten Berge, René A. W. van Lier, Inge Huitinga, Jörg Hamann   +8 more
doaj   +4 more sources

CD8+ Tissue‐Resident Memory T Cells in Health and Disease [PDF]

MedComm
CD8+ tissue‐resident memory T (TRM) cells play a pivotal role in local immune regulation. These noncirculating T cells are uniquely positioned to orchestrate rapid site‐specific immune responses, making them central to understanding tissue‐specific ...
Yu‐Han Ai, Ting‐Ting Xu, Sen Lin, Meng‐Yu Xiao, Yun‐Xia Lin, Hao‐Wen Ma, Yue‐Yang Liu, Yao‐Jie Wang, Lu‐Ning Yin, Mei Huang, Yong‐Da Liu, Chao Zhu, Xiao‐Ting Zhu, Ji‐Hang Yuan   +13 more
doaj   +4 more sources

Ovarian cancer immunogenicity is governed by a narrow subset of progenitor tissue-resident memory T-cells

Cancer Cell, 2022
SUMMARY Despite repeated associations between T-cell infiltration and outcome, human ovarian cancer remains poorly responsive to immunotherapy. We report that hallmarks of tumor recognition in ovarian cancer-infiltrating T-cells are primarily restricted ...
C. Anadon, Xiao-Qing Yu, Kay Hanggi, Subir Biswas, R. Chaurio, Alexandra L Martin, K. Payne, Gunjan Mandal, Patrick Innamarato, C. Harro, J. Mine, K. Sprenger, Carla Cortina, John J. Powers, T. Costich, B. Perez, C. Gatenbee, Sandhya Prabhakaran, D. Marchion, M. Heemskerk, T. Curiel, A. Anderson, R. Wenham, P. Rodriguez, J. Conejo-Garcia   +24 more
semanticscholar   +3 more sources

Site-specific development and progressive maturation of human tissue resident memory T cells over infancy and childhood

Immunity, 2023
SUMMARY Infancy and childhood are critical life stages for generating immune memory to protect against pathogens; however, the timing, location, and pathways for memory development in humans remain elusive. Here, we investigated T cells in mucosal sites,
T. Connors, Rei Matsumoto, Shivali Verma, P. Szabo, Rebecca S. Guyer, Joshua I. Gray, Zicheng Wang, Puspa Thapa, Pranay Dogra, Ma-Ya M. L. Poon, Ksenia Rybkina, Marissa C. Bradley, Emma Idzikowski, James A. McNichols, Masaru Kubota, Kalpana Pethe, Yu-Feng Shen, M. Atkinson, Maigan A. Brusko, T. Brusko, A. Yates, P. Sims, D. Farber   +22 more
semanticscholar   +3 more sources

Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism

Nature, 2017
Tissue-resident memory T (TRM) cells persist indefinitely in epithelial barrier tissues and protect the host against pathogens. However, the biological pathways that enable the long-term survival of TRM cells are obscure. Here we show that mouse CD8+ TRM
You-Dong Pan, T. Tian, C. Park, Serena Y. Lofftus, S. Mei, Xing Liu, C. Luo, J. O'Malley, A. Gehad, J. Teague, S. Divito, R. Fuhlbrigge, P. Puigserver, J. Krueger, Gökhan S. Hotamışlıgil, R. Clark, T. Kupper   +16 more
semanticscholar   +3 more sources

Tissue resident memory T cells populate the human uveal tract [PDF]

Scientific Reports
The current concept is that the eye is an immune privileged site endowed with innate immune regulatory networks to maintain organ function. We now have evidence that resident T cells occupy intraocular tissues.
Andrew D. Foers, Ian R. Reekie, Lakshanie C. Wickramasinghe, Amy Ward, Thomas MW. Buckley, Moustafa Attar, Soledad Aguilar-Munoa, Queen Pilapil, Maram EA. Abdalla Elsayed, Sam Pledger, Ananya Bhalla, Robert Hedley, Sarah Hill, Dylan Windell, Keith Barton, Imran Masood, Kin Sheng Lim, Mark C. Coles, Jonathan P. Sherlock, Andrew D. Dick, Sarah E. Coupland, Stephen N. Sansom, David A. Copland, Christopher D. Buckley, Srilakshmi M. Sharma, ORBIT Consortium   +25 more
doaj   +3 more sources