Multi-omics spatial characteristics of CD8+TRM cells in hepatocellular carcinoma and immunotherapy response prediction [PDF]
Frontiers in ImmunologyIntroductionUnderstanding CD8+ tissue-resident memory T cells (TRM) spatial characteristics in hepatocellular carcinoma (HCC) is challenging, and clarifying the spatial feature changes following immunotherapy represents an urgent research gap.MethodsThis
Shipeng Li +9 more
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Silk fibroin hydrogel as mucosal vaccine carrier: induction of gastric CD4+TRM cells mediated by inflammatory response induces optimal immune protection against Helicobacter felis [PDF]
Emerging Microbes and Infections, 2020 Tissue-resident memory T (TRM) cells, located in the epithelium of most peripheral tissues, constitute the first-line defense against pathogen infections.
Chupeng Hu +9 more
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Novel approach to alleviate lupus nephritis: targeting the NLRP3 inflammasome in CD8+CD69+CD103+ TRM cells [PDF]
Journal of Translational MedicineBackground Renal CD8+ tissue-resident memory T (TRM) cells display prolonged survival and activity in lupus nephritis (LN), exacerbating renal pathology. NLRP3 regulates the T cell response.
Yimei Lai +10 more
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Mature tertiary lymphoid structure associated CD103+ CD8+ Trm cells determined improved anti-tumor immune in breast cancer. [PDF]
Front OncolBackgroundAlthough tertiary lymphoid structures (TLS) play crucial roles in the anti-tumor immune response and are associated with favorable prognoses in many solid tumors, the precise mechanisms by which TLSs enhance anti-tumor immunity remain poorly ...
Fang Q +6 more
europepmc +4 more sources
Human epidermal resident memory T cells: beyond the dermal perspective [PDF]
Frontiers in ImmunologyThe concept of tissue-resident memory T (TRM) cells has fundamentally transformed our understanding of peripheral immune surveillance. Although skin TRM biology has been extensively studied, most investigations have focused on the dermis, whereas the ...
Youichi Ogawa +5 more
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Pathophysiology of Skin Resident Memory T Cells
Frontiers in Immunology, 2021 Tissue resident memory T (TRM) cells reside in peripheral, non-lymphoid tissues such as the skin, where they act as alarm-sensor cells or cytotoxic cells.
Yoshiki Tokura +5 more
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Frontiers in Immunology, 2021 Memory T cells are crucial for both local and systemic protection against pathogens over a long period of time. Three major subsets of memory T cells; effector memory T (TEM) cells, central memory T (TCM) cells, and tissue-resident memory T (TRM) cells ...
Kiyoshi Hirahara +6 more
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Frontiers in Immunology, 2022 The immune system generates memory cells on infection with a virus for the first time. These memory cells play an essential role in protection against reinfection.
Meng Zhang +5 more
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Tissue-resident memory T cells in chronic liver diseases: Phenotype, development and function
Frontiers in Immunology, 2022 Tissue-resident memory (TRM) T cells are a unique subset of memory T cells that are critical for the first line of defense against pathogens or antigens in peripheral non-lymphoid tissues such as liver, gut, and skin.
Yikang Li +3 more
doaj +1 more source
Frontiers in Immunology, 2023 Background and aimsThe key role of tissue-resident memory T (TRM) cells in the immune regulation of hepatocellular carcinoma (HCC) has been investigated and reported, but the regulatory mechanism of tumor microenvironment on TRM cells is still unclear ...
Changjie Yang +11 more
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