Results 21 to 30 of about 4,753,527 (236)

Trials and Tribble-ations of tissue TRM cells [PDF]

Nature Immunology, 2018
CD8+ tissue-resident memory T cells (TRM cells) in two mucosal tissues, the skin and the female reproductive tract, proliferate in situ to generate a secondary pool of TRM cells that does not exit into the circulation.
Jun Siong, Low, Susan M, Kaech
openaire   +2 more sources

Tissue instruction for migration and retention of TRM cells [PDF]

Trends in Immunology, 2015
During infection, a subset of effector T cells seeds the lymphoid and non-lymphoid tissues and gives rise to tissue-resident memory T cells (TRM). Recent findings have provided insight into the molecular and cellular mechanisms underlying tissue instruction of TRM cell homing, as well as the programs involved in their retention and maintenance.
Norifumi, Iijima, Akiko, Iwasaki
openaire   +2 more sources

Glycolysis maintains effector function of lung Th17 TRM cells in precision cut lung slices. [PDF]

iScience
Vaccination with Klebsiella pneumoniae OmpX and the Th17 adjuvant LTA1 elicits lung CD4+ tissue-resident memory (TRM) Th17 cells that provide serotype-independent protection against K. pneumoniae, but vaccine efficacy declines as TRM numbers wane. To define the mechanisms sustaining these cells, we developed an ovalbumin (OVA) model with tetramer ...
Yang H, Kumaran VR, Song K, Remcho TP, Clark RDE, Thakur S, Lu S, Harrison MAA, Iwanaga N, Garcia-Hernandez ML, Rangel-Moreno J, Zwezdaryk KJ, McCombs JE, Norton EB, Kolls JK.   +14 more
europepmc   +4 more sources

Blimp-1 Rather Than Hobit Drives the Formation of Tissue-Resident Memory CD8+ T Cells in the Lungs

Frontiers in Immunology, 2019
Tissue-resident memory CD8+ T (TRM) cells that develop in the epithelia at portals of pathogen entry are important for improved protection against re-infection.
Felix M. Behr, Felix M. Behr, Natasja A. M. Kragten, Thomas H. Wesselink, Benjamin Nota, Rene A. W. van Lier, Derk Amsen, Regina Stark, Pleun Hombrink, Klaas P. J. M. van Gisbergen, Klaas P. J. M. van Gisbergen   +10 more
doaj   +1 more source

NUDT1 promotes the accumulation and longevity of CD103+ TRM cells in primary biliary cholangitis

Journal of Hepatology, 2022
Pyruvate dehydrogenase (PDC)-E2 specific CD8+ T cells play a leading role in biliary destruction in PBC. However, there are limited data on the characterization of these autoantigen-specific CD8+ T cells, particularly in the liver. Herein, we aimed to identify pathogenic intrahepatic CD8+ T-cell subpopulations and investigate their immunobiology in PBC.
Huang, B., Lyu, Z., Qian, Q., Chen, Y., Zhang, J., Li, B., Li, Y., Liang, J., Liu, Q., Li, Y., Chen, R., Lian, M., Xiao, X., Miao, Q., Wang, Q., Fang, J., Lian, Z., Li, Y., Tang, R., Helleday, T., Gershwin, M.E., You, Z., Ma, X.   +22 more
openaire   +3 more sources

Streptococcus lutetiensis inhibits CD8⁺ IL17A⁺ TRM cells and leads to gastric cancer progression and poor prognosis. [PDF]

NPJ Precis Oncol
In many solid tumours, including gastric cancer (GC), the beginning and progression of the tumour are closely correlated with the tumour microbiome. Here, we show the changes in the gastric microbiota and their influence on immune regulation and the promotion of GC progression through 16s rRNA sequencing and single cell RNA sequencing.
Wang H, You W, Zhu Z, Zhang Y, Hu C, Lu J, Huang Y, Peng R, Shan R, Li R, Chen Y, Qi F, Yan F, Zhan Q.   +13 more
europepmc   +4 more sources

IRF4 expression by lung dendritic cells drives acute but not Trm cell–dependent memory Th2 responses

JCI Insight, 2022
Expression of the transcription factor interferon regulatory factor 4 (IRF4) is required for the development of lung conventional DCs type 2 (cDC2s) that elicit Th2 responses, yet how IRF4 functions in lung cDC2s throughout the acute and memory allergic response is not clear.
Daniel F. Camacho, Tania E. Velez, Maile K. Hollinger, Esther Wang, Chanie L. Howard, Eli P. Darnell, Domenick E. Kennedy, Paulette A. Krishack, Cara L. Hrusch, Marcus R. Clark, James J. Moon, Anne I. Sperling   +11 more
openaire   +3 more sources

tissue‐resident memory T cells

, 2021
Brain CD8+ CD69+ tissue-resident memory T (TRM) cells comprise a CD20dim subset, which is proportionally larger in CD103-negative TRM cells. In multiple sclerosis (MS) lesions, CD20dim TRM -cell proportions are increased.
Fransen, NL, Huitinga, I., Smolders, Joost; id_orcid, Hamann, J., Brandwijk, K.I.M., Hamann, J, Hsiao, C.-C., Joost Smolders, Brandwijk, KIM, Smolders, J., Jörg Hamann, Huitinga, I, van den Bosch, A.M.R., Hsiao, CC, Cheng‐Chih Hsiao, Aletta M.R. van den Bosch, Kim I.M. Brandwijk, Bosch, AMR, Nina L. Fransen, Fransen, N.L., Inge Huitinga   +20 more
core   +1 more source

Armed and Ready: Transcriptional Regulation of Tissue-Resident Memory CD8 T Cells

Frontiers in Immunology, 2018
A fundamental benefit of immunological memory is the ability to respond in an enhanced manner upon secondary encounter with the same pathogen. Tissue-resident memory CD8 T (TRM) cells contribute to improved protection against reinfection through the ...
Felix M. Behr, Felix M. Behr, Ammarina Chuwonpad, Regina Stark, Regina Stark, Klaas P. J. M. van Gisbergen, Klaas P. J. M. van Gisbergen   +6 more
doaj   +1 more source

Table_13_HIV specific CD8+ TRM-like cells in tonsils express exhaustive signatures in the absence of natural HIV control.xlsx

, 2022
Lymphoid tissues are an important HIV reservoir site that persists in the face of antiretroviral therapy and natural immunity. Targeting these reservoirs by harnessing the antiviral activity of local tissue-resident memory (TRM) CD8+ T-cells is of great ...
Alex K. Shalek (1291083), Osaretin E. Asowata (11777852), Warren Kuhn (5740346), Bonnie Berger (19458), Philip Goulder (87977), Søren Buus (49944), J. Zachary Porterfield (6904217), Thumbi Ndung’u (159362), Jennifer Giandhari (9543786), Alasdair Leslie (735478), Samita Singh (13974384), Rishan Bipath (13974390), Frank Anderson (4055212), Son Nguyen (525816), Alveera Singh (9442604), Abigail Ngoepe (5740340), Farina Karim (2577766), Andile L. Sibiya (13974387), Dirhona Ramjit (8858981), Kumeshan Moodley (13974393), Ntombifuthi Mthabela (13974381), Sarah K. Nyquist (13777944), Rabiah Fardoos (4678399), Tulio de Oliveira (68362), Henrik N. Kløverpris (9440270), Samuel W. Kazer (1870930)   +25 more
core   +1 more source