Results 11 to 20 of about 4,753,527 (236)

Complexing CpG adjuvants with cationic liposomes enhances vaccine-induced formation of liver TRM cells

Vaccine, 2023
Tissue resident memory T cells (TRM cells) can provide effective tissue surveillance and can respond rapidly to infection. Vaccination strategies aimed at generating TRM cells have shown promise against a range of pathogens. We have previously shown that the choice of adjuvant critically influences CD8+ TRM cell formation in the liver.
Valencia-Hernandez, AM, Zillinger, T, Ge, Z, Tan, PS, Cozijnsen, A, I. McFadden, G, Lahoud, MH, Caminschi, I, Barchet, W, Heath, WR, Fernandez-Ruiz, D   +10 more
core   +5 more sources

Bystander Activation of Pulmonary Trm Cells Attenuates the Severity of Bacterial Pneumonia by Enhancing Neutrophil Recruitment [PDF]

Cell Reports, 2019
Tissue-resident memory T (Trm) cells are described as having a "sensing and alarming" function, meaning they can rapidly release cytokines in response to local cognate antigen recognition, which in turn, draws circulating immune cells into the tissue. Here, we show noncognate, bystander activation can also trigger the sensing and alarming function of ...
Chenghao Ge, Ian R. Monk, Angela Pizzolla, Nancy Wang, James G. Bedford, Timothy P. Stinear, Glen P. Westall, Linda M. Wakim   +7 more
openaire   +5 more sources

CD4+ Resident Memory T Cells Mediate Long-Term Local Skin Immune Memory of Contact Hypersensitivity in BALB/c Mice [PDF]

Frontiers in Immunology, 2020
In allergic contact dermatitis (ACD) and contact hypersensitivity (CHS), the healed skin shows greater swelling than the naïve skin in the same individual upon re-exposure to the same hapten.
Akihiko Murata, Shin-Ichi Hayashi
doaj   +2 more sources

The Role of T_RM Cells in the Pathogenesis of Vitiligo-A Review of the Current State-Of-The-Art. [PDF]

Int J Mol Sci, 2020
Vitiligo is the most common hypopigmentation disease affecting both the skin and mucous membranes. The pathogenesis of this disorder is complex and involves the influence of genetic and environmental factors, oxidative stress, and autoimmune responses. Recent studies have indicated that skin lesions observed in vitiligo tend to recur in the same places
Frączek A, Owczarczyk-Saczonek A, Placek W.   +2 more
europepmc   +5 more sources

TCF1-positive and TCF1-negative TRM CD8 T cell subsets and cDC1s orchestrate melanoma protection and immunotherapy response

Journal for ImmunoTherapy of Cancer
Background Melanoma, the most lethal form of skin cancer, has undergone a transformative treatment shift with the advent of checkpoint blockade immunotherapy (CBI).
Saraí G De León-Rodríguez, Cristina Aguilar-Flores, Julián A Gajón, Ángel Juárez-Flores, Alejandra Mantilla, Raquel Gerson-Cwilich, José Fabián Martínez-Herrera, Diana Alejandra Villegas-Osorno, Claudia T Gutiérrez-Quiroz, Sergio Buenaventura-Cisneros, Mario Alberto Sánchez-Prieto, Edmundo Castelán-Maldonado, Samuel Rivera Rivera, Ezequiel M Fuentes-Pananá, Laura C Bonifaz   +14 more
doaj   +2 more sources

Total Recall: Intestinal T_RM Cells in Health and Disease. [PDF]

Front Immunol, 2020
Tissue-resident memory T cells (TRM cells) have crucial functions in host defense in mucosal tissues. They provide local adaptive immune surveillance and allow the fast initiation of targeted adaptive immune responses in case of antigen re-exposure. Recently, an aberrant activation in the case of immunologically mediated diseases has been increasingly ...
Paap EM, Müller TM, Sommer K, Neurath MF, Zundler S.   +4 more
europepmc   +5 more sources

Clone Wars: Survival of the Fittest CD8+ Trm Cells [PDF]

Immunity, 2021
In this issue of Immunity, Hirai et al. illuminate competition for the cytokine TGFβ as a key regulator of CD8+ tissue-resident memory T cell persistence and occupancy in the skin epidermal niche.
Tiani L, Louis, John T, Chang
openaire   +2 more sources

Total Recall: Intestinal TRM Cells in Health and Disease [PDF]

, 2021
Tissue-resident memory T cells (TRM cells) have crucial functions in host defense in mucosal tissues. They provide local adaptive immune surveillance and allow the fast initiation of targeted adaptive immune responses in case of antigen re-exposure ...
Neurath, Markus F., Müller, Tanja M., Zundler, Sebastian, Sommer, Katrin, Paap, Eva-Maria   +4 more
core   +1 more source

Tissue-Resident T Cells in Chronic Relapsing–Remitting Intestinal Disorders [PDF]

, 2021
Tissue-resident memory T (TRM) cells critically contribute to the rapid immunoprotection and efficient immunosurveillance against pathogens, particularly in barrier tissues, but also during anti-tumor responses. However, the involvement of TRM cells also
Christoph Mueller, Mueller, Christoph, Barreto de Albuquerque, Juliana, Gungor, Bilgi, Juliana Barreto de Albuquerque, de Albuquerque, Juliana Barreto, Bilgi Gungor   +6 more
core   +3 more sources

The Skinny on Fat Trm Cells [PDF]

Immunity, 2017
White adipose tissue (WAT) is exposed to pathogens that breach epithelial barriers, but the role of adipose T cells in immunity isn't clear. In this issue of Immunity, Han et al. (2017) find that WAT harbors a reservoir of memory T cells that provide antimicrobial immunity at the expense of lipid synthesis and metabolism.
Stanley, Cheuk, Liv, Eidsmo
openaire   +2 more sources