Results 31 to 40 of about 4,753,527 (236)

Single-Cell Insights Into Pathogenic Profile of Orchitis and SREBP2-Associated Cholesterol Dysregulation in Spermatogenic Failure. [PDF]

Adv Sci (Weinh)
A first single‐cell atlas of human orchitis reveals coordinated germ‐cell loss, somatic niche dysfunction, and immune‐metabolic remodeling. Aberrant SREBP2 activation in testicular somatic cells emerges as a central pathogenic node, while Fatostatin‐mediated inhibition of the SREBP pathway improves spermatogenesis, fibrosis, and lipid accumulation in a
Tang Y, Jiang Q, Liu Y, Zhang W, Cui L, Lu X, Zhuang Z, Cheng J, Gao S, Fang Y, Hong K, Qiao J, Wang X, Jiang H, Zhang Z, Guo J, Liu Q.   +16 more
europepmc   +2 more sources

IFN-γ–dependent interactions between tissue-intrinsic γδ T cells and tissue-infiltrating CD8 T cells limit allergic contact dermatitis [PDF]

, 2023
BACKGROUND: Elicitation of allergic contact dermatitis (ACD), an inflammatory type 4 hypersensitivity disease, induces skin infiltration by polyclonal effector CD8 αβ T cells and precursors of tissue-resident memory T (TRM) cells.
Llorian, Miriam, Anna Maria Mavrigiannaki, Hayday, Adrian C, Muñoz-Ruiz, Miguel, Iannitto, Maria Luisa, Bethania García-Cassani, D'Antuono, Rocco, Dmitry S. Ushakov, Adrian C. Hayday, García-Cassani, Bethania, Mariam Jamal-Hanjani, Robin Dart, Miguel Muñoz-Ruiz, Hayday, Adrian C., Miriam Llorian, Daniel Davies, McKenzie, Duncan, Ushakov, Dmitry S., Wu, Yin, Duncan McKenzie, Dart, Robin, Anett Jandke, Ushakov, Dmitry S; id_orcid, Davies, Daniel, Pavlova, Anna, Rocco D'Antuono, Maria Luisa Iannitto, Jandke, Anett, Yin Wu, Hayday, Adrian C; id_orcid, Mavrigiannaki, Anna Maria, Jamal-Hanjani, Mariam, Anna Pavlova, García Cassani, Bethania, Wu, Yin; id_orcid, Muñoz Ruiz, Miguel   +35 more
core   +2 more sources

TIGIT Deficiency Protects Mice From DSS-Induced Colitis by Regulating IL-17A–Producing CD4+ Tissue-Resident Memory T Cells

Frontiers in Immunology, 2022
Tissue-resident memory T cells (TRM cells) have been shown to play an instrumental role in providing local immune responses for pathogen clearance in barrier tissues.
Binfeng Chen, Baokui Ye, Mengyuan Li, Shuyi Wang, Jin Li, Yimei Lai, Niansheng Yang, Zunfu Ke, Hui Zhang, Hui Zhang   +9 more
doaj   +1 more source

CD4 TRM Cells Following Infection and Immunization: Implications for More Effective Vaccine Design [PDF]

, 2018
The induction of immunological memory, which is mediated by memory T and B cells, is central to adaptive protective immunity to pathogens induced by previous infection and is the cornerstone of effective vaccine design.
Wilk, Mieszko M., Mieszko M. Wilk, Mills, Kingston, Kingston H. G. Mills, Wilk, Mieszko, Mills, Kingston H. G.   +5 more
core   +1 more source

Table_14_HIV specific CD8+ TRM-like cells in tonsils express exhaustive signatures in the absence of natural HIV control.xlsx

, 2022
Lymphoid tissues are an important HIV reservoir site that persists in the face of antiretroviral therapy and natural immunity. Targeting these reservoirs by harnessing the antiviral activity of local tissue-resident memory (TRM) CD8+ T-cells is of great ...
Alex K. Shalek (1291083), Osaretin E. Asowata (11777852), Warren Kuhn (5740346), Bonnie Berger (19458), Philip Goulder (87977), Søren Buus (49944), J. Zachary Porterfield (6904217), Thumbi Ndung’u (159362), Jennifer Giandhari (9543786), Alasdair Leslie (735478), Samita Singh (13974384), Rishan Bipath (13974390), Frank Anderson (4055212), Son Nguyen (525816), Alveera Singh (9442604), Abigail Ngoepe (5740340), Farina Karim (2577766), Andile L. Sibiya (13974387), Dirhona Ramjit (8858981), Kumeshan Moodley (13974393), Ntombifuthi Mthabela (13974381), Sarah K. Nyquist (13777944), Rabiah Fardoos (4678399), Tulio de Oliveira (68362), Henrik N. Kløverpris (9440270), Samuel W. Kazer (1870930)   +25 more
core   +1 more source

Osteopontin associates with brain TRM-cell transcriptome and compartmentalization in donors with and without multiple sclerosis [PDF]

, 2022
Summary: The human brain is populated by perivascular T cells with a tissue-resident memory T (TRM)-cell phenotype, which in multiple sclerosis (MS) associate with lesions.
Hendrik J. Engelenburg, Huitinga, I., Moerland, Perry D., Smolders, Joost; id_orcid, Zhu, Jing, Hamann, J., Zhu, J., Hsiao, Cheng-Chih, Aldo Jongejan, Zhang, B., Hsiao, Cheng Chih, Joost Smolders, Zhang, Baohong, Mingueneau, M., Moerland, P.D., Smolders, J., Cheng-Chih Hsiao, Jongejan, A., Jörg Hamann, Smolders, Joost, Hsiao, C.C., Jing Zhu, Perry D. Moerland, Jongejan, Aldo, Engelenburg, H.J., Huitinga, Inge, Michael Mingueneau, Baohong Zhang, Engelenburg, Hendrik J., Mingueneau, Michael, Inge Huitinga, Hamann, Jörg   +31 more
core   +1 more source

Establishment and Maintenance of Conventional and Circulation-Driven Lung-Resident Memory CD8+ T Cells Following Respiratory Virus Infections

Frontiers in Immunology, 2019
Antigen-specific CD8+ tissue-resident memory T cells (TRM cells) persist in the lung following resolution of a respiratory virus infection and provide first-line defense against reinfection. In contrast to other memory T cell populations, such as central
Shiki Takamura, Jacob E. Kohlmeier
doaj   +1 more source

Table_10_HIV specific CD8+ TRM-like cells in tonsils express exhaustive signatures in the absence of natural HIV control.xlsx

, 2022
Lymphoid tissues are an important HIV reservoir site that persists in the face of antiretroviral therapy and natural immunity. Targeting these reservoirs by harnessing the antiviral activity of local tissue-resident memory (TRM) CD8+ T-cells is of great ...
Alex K. Shalek (1291083), Osaretin E. Asowata (11777852), Warren Kuhn (5740346), Bonnie Berger (19458), Philip Goulder (87977), Søren Buus (49944), J. Zachary Porterfield (6904217), Thumbi Ndung’u (159362), Jennifer Giandhari (9543786), Alasdair Leslie (735478), Samita Singh (13974384), Rishan Bipath (13974390), Frank Anderson (4055212), Son Nguyen (525816), Alveera Singh (9442604), Abigail Ngoepe (5740340), Farina Karim (2577766), Andile L. Sibiya (13974387), Dirhona Ramjit (8858981), Kumeshan Moodley (13974393), Ntombifuthi Mthabela (13974381), Sarah K. Nyquist (13777944), Rabiah Fardoos (4678399), Tulio de Oliveira (68362), Henrik N. Kløverpris (9440270), Samuel W. Kazer (1870930)   +25 more
core   +1 more source

DataSheet_2_Deep Immune Phenotyping and Single-Cell Transcriptomics Allow Identification of Circulating TRM-Like Cells Which Correlate With Liver-Stage Immunity and Vaccine-Induced Protection From Malaria.zip

, 2022
Protection from liver-stage malaria requires high numbers of CD8+ T cells to find and kill Plasmodium-infected cells. A new malaria vaccine strategy, prime-target vaccination, involves sequential viral-vectored vaccination by intramuscular and ...
Jonathan Sheridan (12052670), Rebecca A. Makinson (12052664), Richard Morter (4766202), Amy Flaxman (12052658), Alexandra J. Spencer (12052676), Mehreen S. Datoo (12052655), Duncan Bellamy (11408480), Adrian V. S. Hill (8955395), Dimitrios Voukantsis (12052673), Daniel Jenkin (12052661), Mohammad Ali Husainy (7600742), Katie J. Ewer (7946855), Fernando Ramos Lopez (12052667), Andrés Noé (3620534), Naveen Prasad (11239158)   +14 more
core   +1 more source

The Roles of Tissue-Resident Memory T Cells in Lung Diseases

Frontiers in Immunology, 2021
The unique environment of the lungs is protected by complex immune interactions. Human lung tissue-resident memory T cells (TRM) have been shown to position at the pathogen entry points and play an essential role in fighting against viral and bacterial ...
Rui Yuan, Jiang Yu, Ziqiao Jiao, Jinfei Li, Fang Wu, Rongkai Yan, Xiaojie Huang, Chen Chen, Chen Chen   +8 more
doaj   +1 more source