Results 1 to 10 of about 27,769 (271)

CD103+CD8+ TRM Cells Accumulate in Tumors of Anti-PD-1-Responder Lung Cancer Patients and Are Tumor-Reactive Lymphocytes Enriched With Tc17

Cell Reports Medicine, 2020
Summary: Accumulation of CD103+CD8+ resident memory T (TRM) cells in human lung tumors has been associated with a favorable prognosis. However, the contribution of TRM to anti-tumor immunity and to the response to immune checkpoint blockade has not been ...
Benjamin Besse, Fathia Mami-Chouaib, David Planchard   +2 more
exaly   +4 more sources

Development of 89Zr-anti-CD103 PET imaging for non-invasive assessment of cancer reactive T cell infiltration [PDF]

Journal for ImmunoTherapy of Cancer, 2022
Purpose CD103, an integrin specifically expressed on the surface of cancer-reactive T cells, is significantly increased during successful immunotherapy across human malignancies.
Danique Giesen, Hans van Eenennaam, Hans W. Nijman, Marco de Bruyn, Arjan Kol, Xiaoyu Fan, Marta A. Wazynska, Sander M.J. van Duijnhoven, Annechien Plat, Philip H. Elsinga   +9 more
doaj   +2 more sources

CD103 Promotes the Pro-Inflammatory Response of Gastric Resident CD4+ T Cell in Helicobacter pylori-Positive Gastritis

Frontiers in Cellular and Infection Microbiology, 2020
CD103 is considered as a surface marker for the resident immune cells. However, little is known about the intrinsic function of CD103 in infection and inflammation.
Zibin Liang, Lan-Lan Geng, Sitang Gong
exaly   +3 more sources

Intratumoral CD103+CD8+ T cells predict response to neoadjuvant chemoimmunotherapy in advanced head and neck squamous cell carcinoma

Cancer Communications, 2023
Background Immune cell heterogenicity is known to determine the therapeutic response to cancer progression. Neoadjuvant chemoimmunotherapy (NACI) has shown clinical benefits in some patients with advanced head and neck squamous cell carcinoma (HNSCC ...
Siqi Ren, Tianjun Lan, Fan Wu, Suling Chen, Xue Jiang, Chuying Huo, Zitian Li, Shule Xie, Donghui Wu, Ruixin Wang, Yanyan Li, Lin Qiu, Guoxin Huang, Shurui Li, Xiaojuan Wang, Meifeng Cen, Tingting Cai, Zhaoyu Lin, Jinsong Li, Bowen Li   +19 more
doaj   +2 more sources

Tissue-Resident Memory CD103+CD8+ T Cells in Colorectal Cancer: Its Implication as a Prognostic and Predictive Liver Metastasis Biomarker

Cancer Immunology, Immunotherapy
Tissue-resident memory CD103+CD8+ T cells (CD103+CD8+ TRMs) are important components of anti-tumor immunity. However, the significance of CD103+CD8+ TRMs in colorectal cancer (CRC) and their advantages remain unclear.
Yun-Long Pan, Jing-Hua Pan
exaly   +2 more sources

Development of [89Zr]Zr-hCD103.Fab01A and [68Ga]Ga-hCD103.Fab01A for PET imaging to noninvasively assess cancer reactive T cell infiltration: Fab-based CD103 immunoPET

EJNMMI Research, 2023
Background CD103 is an integrin specifically expressed on the surface of cancer-reactive T cells. The number of CD103+ T cells significantly increases during successful immunotherapy and might therefore be an attractive biomarker for noninvasive PET ...
Xiaoyu Fan, Marta A. Ważyńska, Arjan Kol, Noemi Perujo Holland, Bruna Fernandes, Sander M. J. van Duijnhoven, Annechien Plat, Hans van Eenennaam, Philip H. Elsinga, Hans W. Nijman, Marco de Bruyn   +10 more
doaj   +2 more sources

Novel approaches to increase resistance to acute respiratory infections

RUDN Journal of Medicine, 2021
Relevance . Respiratory infections are the most common in the world. In order to prevent epidemics, there is a need to improve the strategies for organizing medical care and develop new approaches in order to increase the nonspecific resistance, mobilize
Svetlana V. Guryanova, Natalia A. Kudryashova, Anastasiya A. Kataeva, Bubusaira T. Orozbekova, Natalia V. Kolesnikova, Alexandr G. Chuchalin   +5 more
doaj   +1 more source

Tissue-Resident Memory-Like CD8+ T Cells Exhibit Heterogeneous Characteristics in Tuberculous Pleural Effusion

Journal of Immunology Research, 2021
Tissue-resident memory T (TRM) cells are well known to play critical roles in peripheral tissues during virus infection and tumor immunology. Our previous studies indicated that CD69+CD4+ and CD69+CD8+ T cells in tuberculous pleural effusion (TPE) were ...
Sifei Yu, Suihua Lao, Binyan Yang, Changyou Wu   +3 more
doaj   +1 more source

Tertiary Lymphoid Structure-Associated B Cells Enhance CXCL13+CD103+CD8+ Tissue-Resident Memory T-Cell Response to Programmed Cell Death Protein 1 Blockade in Cancer Immunotherapy.

Gastroenterology, 2023
BACKGROUND & AIMS Although the presence of tertiary lymphoid structures (TLS) correlates with positive responses to immunotherapy in many solid malignancies, the mechanism by which TLS enhances antitumor immunity is not well understood. The present study
Chu-Peng Hu, Wenhua You, Deyuan Kong, Yedi Huang, Jinying Lu, Meng-Ya Zhao, Yu Jin, Rui Peng, Dong Hua, Dong-Ming Kuang, Yun Chen   +10 more
semanticscholar   +1 more source

Combined STING levels and CD103+ T cell infiltration have significant prognostic implications for patients with cervical cancer

OncoImmunology, 2021
Activation of STimulator of INterferon Genes (STING) is important for induction of anti-tumor immunity. A dysfunctional STING pathway is observed in multiple cancer types and associates with poor prognosis and inferior response to immunotherapy. However,
Arjan Kol, Joyce M. Lubbers, Anouk L.J. Terwindt, Hagma H. Workel, Annechien Plat, G. Bea A. Wisman, Joost Bart, Hans W. Nijman, Marco De Bruyn   +8 more
doaj   +1 more source