Results 11 to 20 of about 27,769 (271)

Assessing the role of CD103 in immunity to an intestinal helminth parasite. [PDF]

PLoS ONE, 2011
In the intestine, the integrin CD103 is expressed on a subset of T regulatory (T(reg)) cells and a population of dendritic cells (DCs) that produce retinoic acid and promote immune homeostasis.
Sarah C Mullaly, Kyle Burrows, Frann Antignano, Colby Zaph   +3 more
doaj   +5 more sources

Eribulin mesylate exerts antitumor effects via CD103

OncoImmunology, 2023
Eribulin mesylate (ERB) is a synthetic analog of halichondrin B, inhibiting tumor cell growth by disrupting microtubule function. Recently, anticancer drugs have been shown to not only act directly on tumor cells but also to exert antitumor effects by ...
K. Oya, Yoshiyuki Nakamura, R. Watanabe, R. Tanaka, Y. Ichimura, N. Kubota, Y. Matsumura, H. Tahara, N. Okiyama, M. Fujimoto, T. Nomura, Y. Fujisawa   +11 more
semanticscholar   +5 more sources

CD103 is a hallmark of tumor‐infiltrating regulatory T cells [PDF]

International Journal of Cancer, 2011
AbstractRegulatory T cells (Treg) mediate tolerance towards self‐antigens by suppression of innate and adaptive immunity. In cancer patients, tumor‐infiltrating FoxP3+ Treg suppress local anti‐tumor immune responses and are often associated with poor prognosis.
Anz, David, Mueller, Wolfgang, Golic, Michaela, Kunz, Wolfgang G, Rapp, Moritz, Koelzer, Viktor H, Ellermeier, Jonathan, Ellwart, Joachim W, Schnurr, Max, Bourquin, Carole, Endres, Stefan   +10 more
openaire   +6 more sources

Integrin Alpha E (CD103) Limits Virus-Induced IFN-I Production in Conventional Dendritic Cells [PDF]

Frontiers in Immunology, 2021
Early and strong production of IFN-I by dendritic cells is important to control vesicular stomatitis virus (VSV), however mechanisms which explain this cell-type specific innate immune activation remain to be defined.
Vikas Duhan, Vikas Duhan, Vishal Khairnar, Vishal Khairnar, Simo Kitanovski, Thamer A. Hamdan, Thamer A. Hamdan, Andrés D. Klein, Andrés D. Klein, Judith Lang, Murtaza Ali, Tom Adomati, Hilal Bhat, Hilal Bhat, Sarah-Kim Friedrich, Fanghui Li, Philippe Krebs, Anthony H. Futerman, Marylyn M. Addo, Marylyn M. Addo, Marylyn M. Addo, Cornelia Hardt, Daniel Hoffmann, Philipp A. Lang, Karl S. Lang   +24 more
doaj   +3 more sources

Assessment of compartment-specific CD103-positive cells for prognosis prediction of colorectal cancer

Cancer Immunology, Immunotherapy
Background CD103+ tissue-resident memory T cells was detected in various solid malignancies, like colorectal cancer (CRC), and associated with improved survival.
Anpei Huang, Yuanhui Wu, Ji Cui, Muyan Cai, Yumo Xie, Jialin Zou, Maram Alenzi, Hui Yang, Pinzhu Huang, Meijin Huang   +9 more
doaj   +2 more sources

Essential role for CD103+ cells in the pathogenesis of spondyloarthritides

Joint Bone Spine, 2015
The clinical features of spondyloarthritides include extraarticular manifestations involving the skin, eyes, and gastrointestinal tract. At these sites, a membrane integrin can be acquired by virtue of the presence of CD4+ T cells and specific dendritic cells and correlates with a regulatory behavior of these cells.
Berthelot, Jean-Marie, Le Goff, Benoît, Martin, Jérôme, Maugars, Yves, Josien, Régis   +4 more
openaire   +5 more sources

Apoptotic cells induce CD103 expression and immunoregulatory function in myeloid dendritic cell precursors through integrin αv and TGF-β activation. [PDF]

PLoS ONE, 2020
In the mammalian gut CD103+ve myeloid DCs are known to suppress inflammation threatened by luminal bacteria, but stimuli driving DC precursor maturation towards this beneficial phenotype are incompletely understood.
Ailiang Zhang, Helena Paidassi, Adam Lacy-Hulbert, John Savill   +3 more
doaj   +2 more sources

CD8+CD103+ tissue-resident memory T cells convey reduced protective immunity in cutaneous squamous cell carcinoma

Journal for ImmunoTherapy of Cancer, 2021
Background Tumor infiltrating lymphocytes play a key role in antitumor responses; however, while several memory T-cell subtypes have been reported in inflammatory and neoplastic conditions, the proportional representation of the different subsets of ...
Chester Lai, George Coltart, Andrew Shapanis, Conor Healy, Ahmad Alabdulkareem, Sara Selvendran, Jeffrey Theaker, Matthew Sommerlad, Matthew Rose-Zerilli, Eugene Healy   +9 more
doaj   +2 more sources

CD103 Expression on Regulatory and Follicular T Cells in Lymph Nodes, Bronchoalveolar Lavage Fluid and Peripheral Blood of Sarcoidosis Patients [PDF]

Life, 2022
(1) Background: Sarcoidosis is a chronic multisystem disorder of unknown aetiology, driven by a T-cell mechanism allowing T-cell attachment and transmigration through the endothelium, and endorsed by the expression of an integrin alpha-E beta-7 (CD103 ...
Miriana d’Alessandro, Sara Gangi, Dalila Cavallaro, Laura Bergantini, Fabrizio Mezzasalma, Stefano Cattelan, Stefano Baglioni, Marta Abbritti, Paolo Cameli, Elena Bargagli   +9 more
doaj   +2 more sources

CD103 fate mapping reveals intestinal CD103− tissue-resident memory T cells are the primary responders to secondary infection

Science Immunology, 2022
Tissue-resident memory T (TRM) cells remain poised in the tissue and mediate robust protection from secondary infection. TRM cells within the intestine and other tissues are heterogeneous in their phenotype and function; however, the contributions of ...
Helen Y. Fung, Matthew Teryek, A. Lemenze, Tessa Bergsbaken   +3 more
semanticscholar   +3 more sources