Results 31 to 40 of about 27,769 (271)

Depleting CD103+ resident memory T cells in vivo reveals immunostimulatory functions in oral mucosa

Journal of Experimental Medicine, 2023
In the oral mucosa, Stolley et al. characterize resident memory T cell (TRM) distribution, ontogeny, role in protective immunity, and diverse functions, while describing strategies for locally augmenting or systemically depleting CD103+ TRM.
J. Stolley, M. Scott, V. Joag, Alexander J Dale, T. Johnston, F. Saavedra, Noah V. Gavil, S. Lotfi-Emran, A. Soerens, Eyob Weyu, Mark J Pierson, M. Herzberg, Nu Zhang, V. Vezys, D. Masopust   +14 more
semanticscholar   +1 more source

Interleukin‐37 promotes DMBA/TPA skin cancer through SIGIRR‐mediated inhibition of glycolysis in CD103+DC cells

MedComm, 2023
Interleukin 37 (IL‐37), a member of the IL‐1 family, is considered a suppressor of innate and adaptive immunity and, hence is a regulator of tumor immunity. However, the specific molecular mechanism and role of IL‐37 in skin cancer remain unclear.
F. Zeng, Xiao-Yan Wang, Ya-Wen Hu, Zhen Wang, Ya Li, Jing Hu, Jia-Dong Yu, Pei Zhou, Xiu Teng, Hong Zhou, Huaping Zheng, Fu-Lei Zhao, Lin-na Gu, Cheng-Cheng Yue, Shuwen Chen, Juan Cheng, Yan Hao, Qi-Xiang Zhao, Chen Zhang, Song Zou, Zhong-lan Hu, Xiaoqiong Wei, Xiao Liu, Guo-Lin Li, Nong-Yu Huang, Wen-Ling Wu, Yifan Zhou, W. Li, K. Cui, Jiong Li   +29 more
semanticscholar   +1 more source

A pathogenic role for the integrin CD103 in experimental allergic airways disease [PDF]

, 2016
The integrin CD103 is the αE chain of integrin αEβ7 that is important in the maintenance of intraepithelial lymphocytes and recruitment of T cells and dendritic cells (DC) to mucosal surfaces.
Blank, Fabian, Vanessa S. Fear, Lai, S.P., Perks, K.L., Lai, Siew Ping, Shelley Gorman, Kara L. Perks, Strickland, D.H., Von Garnier, Christophe, Blank, F., Siew Ping Lai, Gorman, S., Gorman, Shelley, Strickland, Deborah H, Stumbles, P.A., Graeme R. Zosky, Zosky, G.R., Zosky, Graeme R, Fear, Vanessa S, Christophe von Garnier, Deborah H. Strickland, Stumbles, Philip A, Perks, Kara L, von Garnier, C., Fear, V.S., Fabian Blank, Philip A. Stumbles, Zosky GR, Strickland DH, Fear VS, Gorman S, von Garnier C, Stumbles PA, Perks KL, Blank F, Lai SP   +35 more
core   +2 more sources

Distribution, phenotype and dysfunctional mechanism of CD8+ CD103+ tissue-resident memory T cells in gastric cancer patients

Di-san junyi daxue xuebao, 2021
Objective To investigate the distribution and phenotypic features of CD8+CD103+ tissue-resident memory T cells (Trm) in gastric cancer (GC) patients, and to explore their dysfunctional mechanism.
SHEN Yang, PENG Liusheng, QIU Yuan, ZOU Quanming, MA Daiyuan   +4 more
doaj   +1 more source

A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism

Journal of Experimental Medicine, 2007
Foxp3+ regulatory T (T reg) cells play a key role in controlling immune pathological re actions. Many develop their regulatory activity in the thymus, but there is also evidence for development of Foxp3+ T reg cells from naive precursors in the periphery.
J. Coombes, K. R. R. Siddiqui, Carolina V. Arancibia-Cárcamo, J. Hall, Cheng-Ming Sun, Y. Belkaid, F. Powrie   +6 more
semanticscholar   +1 more source

CD103+ T Lymphocyte Count Linked to the Thickness of Invasion on Acral Melanoma without E-Cadherin Involvement

Clinical, Cosmetic and Investigational Dermatology, 2021
Fauzan Ali Zainal Abidin, Hermin Aminah Usman, Sri Suryanti, Bethy S Hernowo Department of Anatomical Pathology, Faculty of Medicine, Universitas Padjadjaran/Dr.
Abidin FAZ, Usman HA, Suryanti S, Hernowo BS   +3 more
doaj  

TGF-β: Many Paths to CD103⁺ CD8 T Cell Residency

Cells, 2021
CD8 tissue-resident memory T (TRM) cells primarily reside in nonlymphoid tissues without recirculating and provide front-line protective immunity against infections and cancers. CD8 TRM cells can be generally divided into CD69+ CD103− TRM cells (referred
Zhijuan Qiu, Timothy H. Chu, Brian S. Sheridan   +2 more
doaj   +1 more source

CD103 spurs on suppressors [PDF]

The Journal of Experimental Medicine, 2005
An integrin expressed by gut dendritic cells (DCs) gives regulatory T (T reg) cells the green light for suppression, according to a study on page 1051. Annacker and colleagues show that DCs expressing the integrin CD103 are required for T reg cells to subdue gut-attacking effector T cells in a mouse model of inflammatory bowel disease (IBD).Naturally ...
openaire   +1 more source

A Local Role for CD103+ Dendritic Cells in Atherosclerosis [PDF]

Immunity, 2011
In this issue of Immunity, Choi et al. (2011) analyzed the cellular composition of aortic vessels in normal and atherosclerotic mice, revealing the presence of conventional CD103(+) DCs with a potentially protective influence on atherosclerosis.
Bedoui, Sammy, Heath, William R.
openaire   +2 more sources

TGF-β enhances the cytotoxic activity of Vδ2 T cells

OncoImmunology, 2019
TGF-β is a pleiotropic cytokine with multiple roles in immunity. Apart from its suppressive activity, TGF-β is a driving cytokine in the differentiation of induced regulatory T cells (iTreg) but also in the polarization of interleukin-9 (IL-9) producing ...
Christian Peters, Annika Meyer, Léonce Kouakanou, Julia Feder, Tim Schricker, Marcus Lettau, Ottmar Janssen, Daniela Wesch, Dieter Kabelitz   +8 more
doaj   +1 more source