Results 21 to 30 of about 27,769 (271)

Integrin αE(CD103)β7 in Epithelial Cancer [PDF]

Cancers, 2021
Interactions of both the innate and the adaptive immune system with tumors are complex and often influence courses and therapeutic treatments in unanticipated ways. Based on the concept that CD8+T cells can mediate important antitumor effects, several therapies now aim to amplify their specific activity.
Hoffmann, Johanna C., Schön, Michael P., Hoffmann, Johanna C.; 1Department of Dermatology, Venereology and Allergology, University Medical Center Göttingen, 37075 Göttingen, Germany; johanna.hoffmann@med.uni-goettingen.de, Schön, Michael P.; 1Department of Dermatology, Venereology and Allergology, University Medical Center Göttingen, 37075 Göttingen, Germany; johanna.hoffmann@med.uni-goettingen.de   +3 more
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CD103+ regulatory T cells underlie resistance to radio-immunotherapy and impair CD8+ T cell activation in glioblastoma

Nature Cancer, 2023
Glioblastomas are aggressive primary brain tumors with an inherent resistance to T cell-centric immunotherapy due to their low mutational burden and immunosuppressive tumor microenvironment.
L. van Hooren, Shanna M. Handgraaf, D. Kloosterman, Elham Karimi, Lotte W. H. G. van Mil, A. Gassama, B. Solsona, Marnix H. P. de Groot, D. Brandsma, D. Quail, L. Walsh, G. Borst, L. Akkari   +12 more
semanticscholar   +1 more source

CD103⁺ cells at the forefront of anticancer immunity [PDF]

OncoImmunology, 2017
Owing to their unprecedented success in the management of advanced or metastatic disease, immune checkpoint blockers (ICBs) are being elevated to the rank of standard-of-care for patients affected ...
Claire Vanpouille-Box, Lorenzo Galluzzi
openaire   +3 more sources

Blood Monocyte Subsets Differentially Give Rise to CD103+ and CD103− Pulmonary Dendritic Cell Populations [PDF]

The Journal of Immunology, 2008
Abstract There are two major myeloid pulmonary dendritic cell (DC) populations: CD103+ DCs and CD11bhigh DCs. In this study, we investigated in detail the origins of both myeloid DC pools using multiple experimental approaches. We show that, in resting lung, Ly-6ChighCCR2high monocytes repopulated CD103+ DCs using a CCR2-dependent ...
Claudia, Jakubzick, Frank, Tacke, Florent, Ginhoux, Amy J, Wagers, Nico, van Rooijen, Matthias, Mack, Miriam, Merad, Gwendalyn J, Randolph   +7 more
openaire   +2 more sources

Pivotal role of CD103 in the development of psoriasiform dermatitis [PDF]

Scientific Reports, 2020
AbstractThe integrin αE known as CD103 binds integrin β7 to form the complete heterodimeric integrin molecule αEβ7. CD103 is mainly expressed by lymphocytes within epithelial tissues of intestine, lung, and skin as well as subsets of mucosal and dermal conventional dendritic cells (cDCs).
Fukui, Takehito, Fukaya, Tomohiro, Uto, Tomofumi, Takagi, Hideaki, Nasu, Junta, Miyanaga, Noriaki, Nishikawa, Yotaro, Koseki, Haruhiko, Choijookhuu, Narantsog, Hishikawa, Yoshitaka, Yamashita, Yoshihiro, Sato, Katsuaki   +11 more
openaire   +3 more sources

Expression patterns of CD69 and CD103 among virus-specific CD8⁺ T cells.

, 2022
The expression of CD69 and CD103 on antigen specific CD8+ T cells were assessed by flow cytometry across all experimental groups. (A-E) Average percentage of CD69-CD103-, CD69+CD103-, CD69-CD103+ and CD69+CD103+ antigen-specific (CM9) CD8+ T cells after ...
Alexandra M. Ortiz (10777105), Amy Ransier (3723697), Daniel C. Douek (8528145), Jennifer Simpson (2927841), Carly E. Starke (12378801), Jason M. Brenchley (8704194), Sam Darko (517525)   +6 more
core   +1 more source

Retinoic acid signaling during priming licenses intestinal CD103+ CD8 TRM cell differentiation

Journal of Experimental Medicine, 2023
Qiu et al. demonstrate that retinoic acid signaling during T cell priming in the mesenteric lymph nodes licenses the differentiation of CD103+ CD8 tissue-resident memory T cells after entry into the small intestine, which may improve rational vaccine ...
Zhi-Juan Qiu, Camille Khairallah, Timothy H. Chu, Jessica N Imperato, Xin-Yuan Lei, Galina Romanov, A. Atakilit, L. Puddington, B. Sheridan   +8 more
semanticscholar   +1 more source

The origin and development of nonlymphoid tissue CD103+ DCs [PDF]

Journal of Experimental Medicine, 2009
CD103+ dendritic cells (DCs) in nonlymphoid tissues are specialized in the cross-presentation of cell-associated antigens. However, little is known about the mechanisms that regulate the development of these cells. We show that two populations of CD11c+MHCII+ cells separated on the basis of CD103 and CD11b expression coexist in most nonlymphoid tissues
Ginhoux, Florent, Liu, Kang, Helft, Julie, Bogunovic, Milena, Greter, Melanie, Hashimoto, Daigo, Price, Jeremy, Yin, Na, Bromberg, Jonathan, Lira, Sergio A., Stanley, E. Richard, Nussenzweig, Michel, Merad, Miriam   +12 more
openaire   +2 more sources

CD103 and CD39 coexpression identifies neoantigen-specific cytotoxic T cells in colorectal cancers with low mutation burden

Journal for ImmunoTherapy of Cancer, 2023
Background Expression of CD103 and CD39 has been found to pinpoint tumor-reactive CD8+ T cells in a variety of solid cancers. We aimed to investigate whether these markers specifically identify neoantigen-specific T cells in colorectal cancers (CRCs ...
J. van den Bulk, Manon van der Ploeg, M. Ijsselsteijn, D. Ruano, R. van der Breggen, Rebekka Duhen, K. Peeters, A. Fariña-Sarasqueta, E. Verdegaal, S. van der Burg, Thomas Duhen, N. D. de Miranda   +11 more
semanticscholar   +1 more source

CD103 in the development of experimental asthma [PDF]

Allergy, Asthma & Clinical Immunology, 2010
Objective/purpose CD103 (Alpha-E Beta-7 integrin) is expressed on various cell types involved in the development of asthma, including dendritic cells (DCs) and CD4 and CD8 T regulatory cells. This integrin binds E-cadherin on epithelial cells and plays a role in regulating the migration and proliferation of cells.
Blanchet Marie-Renee, Gold Matthew, Bennett Jami, McNagny Kelly   +3 more
openaire   +2 more sources