Results 41 to 50 of about 27,769 (271)

Vaccine efficacy against primary and metastatic cancer with in vitro-generated CD103+ conventional dendritic cells

Journal for ImmunoTherapy of Cancer, 2020
Background Type 1 conventional dendritic cells (cDC1s) possess efficient antigen presentation and cross-presentation activity, as well as potent T cell priming ability.
Eugenie S Kleinerman, Yifan Zhou, Natalie Slone, Taylor T Chrisikos, Oleksandr Kyrysyuk, Rachel L Babcock, Yusra B Medik, Haiyan S Li, Stephanie S Watowich   +8 more
doaj   +1 more source

IgA2 immune complexes selectively promote inflammation by human CD103+ dendritic cells

Frontiers in Immunology, 2023
While immunoglobulin A (IgA) is well known for its neutralizing and anti-inflammatory function, it is becoming increasingly clear that IgA can also induce human inflammatory responses by various different immune cells.
Lynn Mes, U. Steffen, Hung-Jen Chen, J. Veth, Willianne Hoepel, G. Griffith, G. Schett, J. den Dunnen   +7 more
semanticscholar   +1 more source

CD103+ tumor-infiltrating lymphocytes are tumor-reactive intraepithelial CD8+ T cells associated with prognostic benefit and therapy response in cervical cancer

OncoImmunology, 2017
Human papilloma virus (HPV)-induced cervical cancer constitutively expresses viral E6/E7 oncoproteins and is an excellent target for T cell-based immunotherapy. However, not all tumor-infiltrating T cells confer equal benefit to patients, with epithelial
Fenne L. Komdeur, Thalina M. Prins, Stephanie van de Wall, Annechien Plat, G. Bea A. Wisman, Harry Hollema, Toos Daemen, David N. Church, Marco de Bruyn, Hans W. Nijman   +9 more
doaj   +1 more source

Hypersensitivity pneumonitis onset and severity is regulated by CD103 dendritic cell expression. [PDF]

PLoS ONE, 2017
Pulmonary dendritic cells drive lung responses to foreign antigens, including Saccharopolyspora rectivirgula, a causative agent of hypersensitivity pneumonitis.
Emilie Bernatchez, Anick Langlois, Julyanne Brassard, Nicolas Flamand, David Marsolais, Marie-Renée Blanchet   +5 more
doaj   +1 more source

4-1BB Agonism Combined With PD-L1 Blockade Increases the Number of Tissue-Resident CD8+ T Cells and Facilitates Tumor Abrogation

Frontiers in Immunology, 2020
Although the milestone discovery of immune checkpoint blockade (ICB) has been translated into clinical practice, only a fraction of patients can benefit from it with durable responses and subsequent long-term survival.
Qiu-xia Qu, Qiu-xia Qu, Xin-yun Zhu, Wen-wen Du, Hong-bin Wang, Yu Shen, Yu Shen, Yi-bei Zhu, Cheng Chen   +8 more
doaj   +1 more source

Intratumoral CD103+ CD8+ T cells predict response to PD-L1 blockade

Journal for ImmunoTherapy of Cancer, 2021
Background CD8+ tissue-resident memory T (TRM) cells, marked by CD103 (ITGAE) expression, are thought to actively suppress cancer progression, leading to the hypothesis that their presence in tumors may predict response to immunotherapy. Methods Here, we
R. Banchereau, Avantika Chitre, A. Scherl, Thomas D. Wu, N. Patil, P. D. de Almeida, E. Kadel, Shravan Madireddi, A. Au-Yeung, C. Takahashi, Y. Chen, Z. Modrusan, J. McBride, Rhea Nersesian, E. Elgabry, Mark D. Robida, Jeffrey Hung, M. Kowanetz, W. Zou, M. Mccleland, P. Caplazi, Shadi Toghi Eshgi, H. Koeppen, P. Hegde, I. Mellman, W. Mathews, T. Powles, S. Mariathasan, J. Grogan, W. O'Gorman   +29 more
semanticscholar   +1 more source

How to generate large numbers of CD103+ dendritic cells [PDF]

Blood, 2014
In this issue of Blood, Mayer et al describe a new method of generating high numbers of Batf3- and Irf8-dependent CD103+ conventional dendritic cells (cDCs), providing new opportunities to study this subset of antigen-presenting cells specialized in crosspresentation.
Lianne van de Laar, Bart N. Lambrecht
openaire   +3 more sources

CD8+CD103+PD1+TIM3+ T cells in glioblastoma microenvironment correlate with prognosis

Immunology, 2023
Glioblastoma, isocitrate dehydrogenase‐wildtype (GB), is the most common and aggressive primary brain malignancy with poor outcome. Immune checkpoint inhibitors (ICIs) have been tested in GB and, despite disappointing results, the identification of a ...
G. Romagnoli, Q. G. D'Alessandris, Imerio Capone, A. Tavilla, I. Canini, C. Lapenta, M. Buccarelli, Martina Giordano, Valentina Tirelli, Massimo Sanchez, A. Fragale, S. Giannetti, R. Di Bonaventura, L. Lauretti, M. Biffoni, L. Ricci-Vitiani, R. Pallini, L. Gabriele   +17 more
semanticscholar   +1 more source

Étude de la signalisation de l'intégrine αE(CD103)β7 dans les lymphocytes T cytotoxiques anti-tumoraux

, 2017
The alphaE(CD103)beta7 integrin plays a crucial role in the formation of a functional immune synapse (IS) between T cells and epithelial target cells.
Gauthier, Ludiane
core   +2 more sources

Intratumoral CD103+CD4+ T cell infiltration defines immunoevasive contexture and poor clinical outcomes in gastric cancer patients

OncoImmunology, 2020
Our previous study has identified intratumoral CD103+CD8+ T cells as a favorable prognostic factor in gastric cancer. However, the significance of CD103+CD4+ T cells in gastric cancer hasn’t yet been elucidated. Here, we aimed to investigate the clinical
Yun Gu, Yifan Chen, Kaifeng Jin, Yifan Cao, Xin Liu, Kunpeng Lv, Xudong He, Chao Lin, Hao Liu, He Li, Hongyong He, Jing Qin, Ruochen Li, Heng Zhang, Weijuan Zhang   +14 more
doaj   +1 more source