Results 61 to 70 of about 27,769 (271)

Formation and phenotypic characterization of CD49a, CD49b and CD103 expressing CD8 T cell populations in human metastatic melanoma

OncoImmunology, 2018
Integrins α1β1 (CD49a), α2β1 (CD49b) and αEβ7 (CD103) mediate retention of lymphocytes in peripheral tissues, and their expression is upregulated on tumor infiltrating lymphocytes (TIL) compared to circulating lymphocytes.
Marit M. Melssen, Walter Olson, Nolan A. Wages, Brian J. Capaldo, Ileana S. Mauldin, Adela Mahmutovic, Ciara Hutchison, Cornelis J.M. Melief, Timothy N. Bullock, Victor H. Engelhard, Craig L. Slingluff   +10 more
doaj   +1 more source

Intrahepatic Tissue‐Resident CD8+ T‐Cell Programmes Associate With Fibrosis and Local Immune Remodelling in Autoimmune Hepatitis [PDF]

Liver Int
ABSTRACT Background and Aims Autoimmune hepatitis is an immune‐mediated liver disease characterized by chronic inflammation and progressive fibrosis. Tissue‐resident memory T cells mediate organ‐specific immunity, but their role in autoimmune hepatitis remains poorly understood.
Stary V, Losek S, Mairinger M, Prager G, Santol J, Starlinger P, Reiberger T, Stättermayer A, Stary G.   +8 more
europepmc   +2 more sources

Mature tertiary lymphoid structure associated CD103+ CD8+ Trm cells determined improved anti-tumor immune in breast cancer

Frontiers in Oncology
Background Although tertiary lymphoid structures (TLS) play crucial roles in the anti-tumor immune response and are associated with favorable prognoses in many solid tumors, the precise mechanisms by which TLSs enhance anti-tumor immunity remain poorly ...
Q. Fang, Shu-Ru Chen, Xiaoyu Chen, Wei Zou, Di Chen, Yu-Kang Huang, Chu-Cheng Wu   +6 more
semanticscholar   +1 more source

NUDT1 promotes the accumulation and longevity of CD103+ TRM cells in primary biliary cholangitis.

Journal of Hepatology, 2022
BACKGROUND & AIMS PDC-E2 specific CD8+ T cells play a leading role in biliary destruction in PBC. However, there are limited data on characterization of these autoantigen specific CD8+ T cells, particularly in liver.
Bing-Yuan Huang, Zhuwan Lyu, Qi-Wei Qian, Yong Chen, Jun Zhang, Bo Li, Yi-Kang Li, Ju-Bo Liang, Qiao-Yan Liu, You Li, Rui-Ling Chen, M. Lian, X. Xiao, Q. Miao, Qi-Xia Wang, Jing-Yuan Fang, Zhe-Xiong Lian, Yan-Mei Li, R. Tang, T. Helleday, M. Gershwin, Z. You, Xiong Ma   +22 more
semanticscholar   +1 more source

CX3CR1+c-kit+ Bone Marrow Cells Give Rise to CD103+ and CD103− Dendritic Cells with Distinct Functional Properties [PDF]

The Journal of Immunology, 2008
Abstract Dendritic cells (DC) represent a rather heterogeneous cell population with regard to morphology, phenotype, and function and, like most cells of the immune system, are subjected to a continuous renewal process. CD103+ (integrin αE) DC have been identified as a major mucosal DC subset involved in the induction of tissue-specific ...
Maria-Luisa, del Rio, Jose-Ignacio, Rodriguez-Barbosa, Jasmin, Bölter, Matthias, Ballmaier, Oliver, Dittrich-Breiholz, Michael, Kracht, Steffen, Jung, Reinhold, Förster   +7 more
openaire   +2 more sources

Exposure to the antimicrobial peptide LL-37 produces dendritic cells optimized for immunotherapy

OncoImmunology, 2019
Immunization of patients with autologous, ex vivo matured dendritic cell (DC) preparations, in order to prime antitumor T-cell responses, is the focus of intense research.
Emily Gwyer Findlay, Andrew J. Currie, Ailiang Zhang, Jana Ovciarikova, Lisa Young, Holly Stevens, Brian J. McHugh, Marta Canel, Mohini Gray, Simon W.F. Milling, John D.M. Campbell, John Savill, Alan Serrels, Donald J. Davidson   +13 more
doaj   +1 more source

Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors

Nature Communications, 2018
Identifying tumor antigen-specific T cells from cancer patients has important implications for immunotherapy diagnostics and therapeutics. Here, we show that CD103+CD39+ tumor-infiltrating CD8 T cells (CD8 TIL) are enriched for tumor-reactive cells both ...
Thomas Duhen, Rebekka Duhen, R. Montler, Jake Moses, T. Moudgil, N. D. de Miranda, C. Goodall, T. Blair, B. Fox, J. Mcdermott, Shu-Ching Chang, G. Grunkemeier, R. Leidner, R. Bell, A. Weinberg   +14 more
semanticscholar   +1 more source

IL-2Rβ-dependent signaling and CD103 functionally cooperate to maintain tolerance in the gut mucosa

, 2015
A network of mechanisms operates to maintain tolerance in the gut mucosa. Although CD103 marks many lymphoid cells within the gut, its direct functional role in intestinal tolerance is poorly understood. CD103 may be part of a redundant pathway, as CD103(
Altman, Norman H, Dee, Michael J, Yuan, Xiaomei, Malek, Thomas R   +3 more
core   +1 more source

Integrin CD103 expression in naïve CD8+ T cells promotes cytokine-driven acquisition of memory phenotype and effector function

Immunity
Integrin CD103 binds to E-cadherin, a cell adhesion molecule predominantly expressed on epithelial cells, thus mediating the tissue-residency of CD103+ T cells in barrier sites.
Can Li, Davinna L. Ligons, Dominic Lanasa, Hilary R. Keller, Megan A. Luckey, Brian J. Capaldo, D. Meerzaman, J. Park, Jung-Hyun Park   +8 more
semanticscholar   +1 more source

Discovery of highly immunogenic spleen-resident FCGR3+CD103+ cDC1s differentiated by IL-33-primed ST2+ basophils

Cellular & Molecular Immunology, 2023
Recombinant interleukin-33 (IL-33) inhibits tumor growth, but the detailed immunological mechanism is still unknown. IL-33-mediated tumor suppression did not occur in Batf3^−/− mice, indicating that conventional type 1 dendritic cells (cDC1s) play a key ...
Myeong-Ho Kang, JungHyub Hong, Jinjoo Lee, Min-Suk Cha, Sang-Ho Lee, H. Kim, S. Ha, Yong-Taik Lim, Y. Bae   +8 more
semanticscholar   +1 more source