Results 81 to 90 of about 27,769 (271)

Subsets of migrating intestinal dendritic cells [PDF]

, 2010
Dendritic cells (DCs) in the intestine are heterogeneous. Phenotypically different populations of conventional DCs have been identified in the intestinal lamina propria, Peyer's patches, and in the draining mesenteric lymph nodes, to which these DCs ...
Yrlid, Ulf, Cerovic, Vuk, MacPherson, Gordon, Milling, Simon, Yrlid, Ulf,   +4 more
core   +1 more source

Functional Heterogeneity of CD4+ Tumor-Infiltrating Lymphocytes With a Resident Memory Phenotype in NSCLC

Frontiers in Immunology, 2018
Resident memory T cells (TRM) inhabit peripheral tissues and are critical for protection against localized infections. Recently, it has become evident that CD103+ TRM are not only important in combating secondary infections, but also for the elimination ...
Anna E. Oja, Berber Piet, David van der Zwan, Hans Blaauwgeers, Mark Mensink, Sander de Kivit, Jannie Borst, Martijn A. Nolte, René A. W. van Lier, Regina Stark, Pleun Hombrink   +10 more
doaj   +1 more source

Spatial features of specific CD103+CD8+ tissue-resident memory T cell subsets define the prognosis in patients with non-small cell lung cancer

Journal of Translational Medicine
Background Tissue-resident memory T (T_RM) cells can reside in the tumor microenvironment and are considered the primary response cells to immunotherapy. Heterogeneity in functional status and spatial distribution may contribute to the controversial role
Guan-Qun Yang, Si-Qi Cai, Mengyu Hu, Chao-Zhuo Li, Li-Ying Yang, Wei Zhang, Jujie Sun, Fenghao Sun, Li-Gang Xing, Xiao-Rong Sun   +9 more
semanticscholar   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Essential role for CD103 in the T cell-mediated regulation of experimental colitis.

, 2005
The integrin CD103 is highly expressed at mucosal sites, but its role in mucosal immune regulation remains poorly understood. We have analyzed the functional role of CD103 in intestinal immune regulation using the T cell transfer model of colitis.
Bengt Johansson-Lindbom, Parker, CM, Johansson-Lindbom, B, Fiona Powrie, Agace, William, Oliver Annacker, Holm H. Uhlig, Uhlig, HH, Johansson Lindbom, Bengt, Tim Bourne, Malmstrom, V, Janine L. Coombes, Agace, William,, Vivianne Malmstrom, Powrie, F, William W. Agace, Coombes, JL, Agace, WW, Annacker, O, Bourne, T, Christina M. Parker, Johansson Lindbom, Bengt,, Lund University.   +22 more
core   +1 more source

Functionally impaired CD103+CD39+CD8+ T cell subsets with immune-suppressive properties infiltrating gastric cancer tissues promote tumor progression

陆军军医大学学报
Objective To detect the infiltration level of CD103+CD39+CD8+ T cell subsets in gastric cancer tissues and analyze their response characteristics, clarifying the clinical relevance of this subset.
HUANG Mengqiu, ZHONG Hang
doaj   +1 more source

Gut Helicobacter presentation by multiple dendritic cell subsets enables context-specific regulatory T cell generation

eLife, 2021
Generation of tolerogenic peripheral regulatory T (pTreg) cells is commonly thought to involve CD103+ gut dendritic cells (DCs), yet their role in commensal-reactive pTreg development is unclear.
Emilie V Russler-Germain, Jaeu Yi, Shannon Young, Katherine Nutsch, Harikesh S Wong, Teresa L Ai, Jiani N Chai, Vivek Durai, Daniel H Kaplan, Ronald N Germain, Kenneth M Murphy, Chyi-Song Hsieh   +11 more
doaj   +1 more source

CD69+CD103+CD8+ tissue-resident memory T cells possess stronger anti-tumor activity and predict better prognosis in colorectal cancer

Cell Communication and Signaling
Colorectal cancer (CRC) is one of the most prevalent cancers worldwide. Despite advancements in therapeutic methodologies, it still causes a high rate of patient mortality. CD8+ tissue-resident memory T (TRM) cells are strategically positioned to mediate
Zixiang Wu, Tian-Tian Da, Chuan Huang, Xiao-Qing Wang, Liang Li, Zhi-Bin Zhao, Ting-Ting Yin, Haijun Ma, Zhe-Xiong Lian, Jie Long, Fei Wang, Jie Cao   +11 more
semanticscholar   +1 more source

Single-cell Profiles and Prognostic Impact of Tumor-Infiltrating Lymphocytes Coexpressing CD39, CD103, and PD-1 in Ovarian Cancer

Clinical Cancer Research, 2021
Purpose: Tumor-infiltrating lymphocytes (TIL) are strongly associated with survival in most cancers; however, the tumor-reactive subset that drives this prognostic effect remains poorly defined.
Céline M. Laumont, M. Wouters, Julian Smazynski, Nicole S. Gierc, E. Chavez, Lauren Chong, Shelby Thornton, K. Milne, J. Webb, C. Steidl, B. Nelson   +10 more
semanticscholar   +1 more source

Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte‐to‐DC Differentiation Via Microbiota‐Associated IAA

Advanced Science, EarlyView.
Lactiplantibacillus plantarum GUANKE remodels the indigenous gut microbiota and is associated with microbiota‐dependent restoration of circulating IAA. IAA treatment attenuates JAK3‐STAT3 and Jag1‐Notch4‐Hey1 signaling and reduces CX3CR1+Ly6C− monocytic precursor generation and pulmonary CD11b+ DC accumulation, together with reduced Th2 inflammation ...
Yujia He, Jielan Mi, Zhiping Zhao, Xiao Zhang, Zhihan Yang, Kun Yue, Yuanming Huang, Liqiong Song, Xiaoting Wen, Jianguo Xu, Zhihong Ren   +10 more
wiley   +1 more source