Results 101 to 110 of about 27,769 (271)

Exposure to the Gram-Negative Bacteria Pseudomonas aeruginosa Influences the Lung Dendritic Cell Population Signature by Interfering With CD103 Expression

Frontiers in Cellular and Infection Microbiology, 2021
Lung dendritic cells (DCs) are divided into two major populations, which include CD103+XCR1+ cDC1s and CD11b+Sirpα+ cDC2s. The maintenance of their relative proportions is dynamic and lung inflammation, such as caused by exposure to lipopolysaccharide ...
Julyanne Brassard, Joanny Roy, Anne-Marie Lemay, Marie-Josée Beaulieu, Emilie Bernatchez, Marc Veillette, Caroline Duchaine, Marie-Renée Blanchet   +7 more
doaj   +1 more source

Radiation‐Triggered Chemokine‐Secreting Probiotics for Boron Neutron Capture Therapy Based Radioimmunotherapy

Advanced Science, EarlyView.
Engineered Escherichia coli Nissle 1917 with a tannic acid‐mediated BPA coating enables tumor‐targeted boron delivery for BNCT. The low‐level incidental radiation generated during BNCT activate a RecA‐driven circuit to induce CXCL10, while radiation‐enhanced bacterial colonization triggers in situ vaccination and systemic antitumor immunity.
Yang Liu, Yuzhong Qian, Shaobo Huang, Bingbing Li, Yue Yu, Xiang Cheng, Chang Chen, Jiheng Wang, Maosong Yang, Lizheng Liang, Xiancai Meng, Zhigang Liu   +11 more
wiley   +1 more source

Diagnostic value of CD103 expression in bronchoalveolar lymphocytes in sarcoidosis [PDF]

Respiratory Medicine, 2012
Pulmonary sarcoidosis is frequently characterized by a CD4(+)/CD8(+) ratio ≥3.5 in bronchoalveolar lavage fluid (BALF), although up to 40% of the cases present a normal or even decreased ratio, pointing out its variability and limitation as a diagnostic marker for sarcoidosis.
Mota, Patrícia Caetano, Morais, António, Palmares, Carmo, Beltrão, Marília, Melo, Natália, Santos, Ana Cristina, Delgado, Luís   +6 more
openaire   +2 more sources

CCL25/CCR9 promotes the induction and function of CD103 on intestinal intraepithelial lymphocytes.

, 2004
The integrin CD103 and the chemokine receptor CCR9 are co-expressed on small intestinal CD8+ intraepithelial lymphocytes (IEL), naïve murine CD8+ T cells and by a small population of effector/memory CD8+ T cells, indicating a potential role for CCR9 in ...
Arya, Anu, Svensson Frej, Marcus,, Ericsson, Anna,, Agace, William, Svensson Frej, Marcus, Ericsson, Anna, Lund University., Agace, William,   +7 more
core   +1 more source

TGFβR signalling controls CD103+CD11b+ dendritic cell development in the intestine [PDF]

, 2017
CD103+CD11b+ dendritic cells (DCs) are unique to the intestine, but the factors governing their differentiation are unclear. Here we show that transforming growth factor receptor 1 (TGFβR1) has an indispensable, cell intrinsic role in the development of ...
Zangerle-Murray, T.F.P., J. Montgomery, Bain, CC, Girard Madoux, Mathilde, Mowat, A. Mcl., Bain, L.J. (Lisa), Lawrence, T., Bain, C.C., J. N. Samsom, Malissen, B, Martens, L., Kel, J., Bain, C., Ober-Blöbaum, J.L. (Julia), Scott, C. L., J. Ober-Blöbaum, Montgomery, J, Henri, S, Y. Saeys, Lindenbergh-Kortleve, D, Mowat, Allan McI., Mowat, Alan McI., Kel, J.M., Girard-Madoux, M.J.H., Zangerle-Murray, T F P, Zangerle-Murray, T., Saeys, Yvan, Kel, JM, Martens, L. (Liesbet), B. E. Clausen, Scott, Charlotte, Samsom, J N, A. McI. Mowat, Kel, Junda, Zangerle-Murray, TFP, Girard-Madoux, M., Clausen, B.E., Clausen, B.E. (Bjorn), Montgomery, J., Clausen, B., Martens, Liesbet, Kel, J. M., Ober-Blobaum, J, Clausen, Björn, Mowat, A.M. (A. McI.), Clausen, BE, T. Lawrence, Malissen, B., Lawrence, T. (Toby), Girard-Madoux, M J H, Henri, Sandrine, Saeys, Y. (Yvan), Sansom, J.N., Girard-Madoux, M.J.H. (Mathilde), Ober-Blöbaum, J., Samsom, J. N., T. F. P. Zangerle-Murray, Scott, C., Lawrence, T, Zangerle-Murray, T. F. P., Samsom, J., D. Lindenbergh-Kortleve, M. Dalod, Kel, J M, Bain, C. C., Lindenbergh-Kortleve, D., J. M. Kel, Ober-Blöbaum, Julia, Girard-Madoux, MJH, C. L. Scott, Malissen, B. (Bernard), Scott, CL, Martens, L, Clausen, B. E., Samsom, JN, Girard-Madoux, M. J. H., M. J. H. Girard-Madoux, Mowat, AM, Montgomery, J. (J.), Mowat, A Mcl, Mowat, A. Mci., Saeys, Y., Saeys, Y, Malissen, Bernard, Samsom, J.N. (Janneke), Henri, S. (Sandrine), Samsom, Janneke, Clausen, B E, B. Malissen, Dalod, M., Scott, C.L. (C.), Zangerle-Murray, T.F.P. (T. F.P.), S. Henri, Kel, J.M. (Junda), Lindenbergh-Kortleve, D.J. (Dicky), Dalod, M. (Marc), C. C. Bain, Henri, S., Scott, C L, Dalod, M, L. Martens   +100 more
core   +1 more source

Unconventional human CD61 pairing with CD103 promotes TCR signaling and antigen-specific T cell cytotoxicity

Nature Immunology
Cancer remains one of the leading causes of mortality worldwide, leading to increased interest in utilizing immunotherapy strategies for better cancer treatments.
M. A. Hamid, Pablo F. Cespedes, Chen Jin, Ji-Li Chen, U. Gileadi, E. Antoun, Zhu Liang, Fei Gao, Renuka Teague, N. Manoharan, D. Maldonado-Pérez, Nasullah Khalid Alham, L. Cerundolo, Raul Ciaoca, Svenja S. Hester, Adán Pinto-Fernández, Simeon D. Draganov, I. Vendrell, Gui-Hai Liu, Xuan Yao, Audun Kvalvaag, Delaney C C Dominey-Foy, Charunya Nanayakkara, N. Kanellakis, Yi-Ling Chen, C. Waugh, Sally-Ann Clark, Kevin Clark, P. Sopp, Najib M. Rahman, C. Verrill, B. Kessler, Graham S. Ogg, Ricardo A. Fernandes, R. Fisher, Yan-Chun Peng, Michael L. Dustin, Tao Dong   +37 more
semanticscholar   +1 more source

Ultrasound‐Activated Nanoinhibitors Blocking the Chemo‐Immune Checkpoint to Overcome Chemotherapy‐Induced Immune Resistance

Advanced Science, EarlyView.
A sono‐responsive chemo‐immune checkpoint nanoinhibitor (Sono‐TT8) co‐delivering TPZ chemotherapy and siXkr8 simultaneously kills tumor cells and blocks PS externalization, reversing chemotherapy‐induced immunosuppression and enhancing antitumor immunity. ABSTRACT Breast cancer features an immunosuppressive tumor microenvironment following chemotherapy
Yunfan Liu, Chier Du, Leilei Zhu, Hongjin An, Shengzhe Hou, Yi Lan, Xuemei Tang, Min Xu, Peng Luo, Hua Teng, Hao Yang, Xun Guo, Jianli Ren, Zhiyi Zhou   +13 more
wiley   +1 more source

Magnetic Thermal Ablation Combined with Temporally Coordinated CpG Immunotherapy Promotes cDC1‐Dependent Immune Priming in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Novel PLA@Fe3O4 magnetic microspheres were developed for transarterial magnetic hyperthermia ablation (MTA) of hepatocellular carcinoma. While destroying local tumors and inducing immunogenic cell death (ICD), MTA combined with early CpG adjuvant administration significantly promotes cDC1‐dependent immune priming. This synergistic mechanism effectively
Jiakun Yang, Nailin Yang, Shuangshuang Ji, Siping Meng, Di Wang, Wenjun Liang, Xuming Bai, Yong Jin, Xingwei Sun   +8 more
wiley   +1 more source

TGF-β and IL-12 conversely orchestrate the formation of CD103+ CD8 tumor-resident memory T cells to regulate response to therapeutic cancer vaccine

iScience
Summary: The accumulation of CD103+ CD8 tumor-resident memory T (TRM) cells is predictive of response to cancer immunotherapy. Here, we show that a therapeutic peptide vaccine controls tumor growth in wild-type mice, but not in CD103-knockout mice.
Stéphanie Corgnac, Isabelle Damei, Chiara Gentile, Aziza Caidi, Séverine Badel, Mélanie Phayanouvong, Fathia Mami-Chouaib   +6 more
doaj   +1 more source

Intestinal CD103+ dendritic cells are key players in the innate immune control of Cryptosporidium parvum infection in neonatal mice. [PDF]

PLoS Pathogens, 2013
Cryptosporidium parvum is a zoonotic protozoan parasite found worldwide, that develops only in the gastrointestinal epithelium and causes profuse diarrhea. Using a mouse model of C.
Louis Lantier, Sonia Lacroix-Lamandé, Laurent Potiron, Coralie Metton, Françoise Drouet, William Guesdon, Audrey Gnahoui-David, Yves Le Vern, Edith Deriaud, Aurore Fenis, Sylvie Rabot, Amandine Descamps, Catherine Werts, Fabrice Laurent   +13 more
doaj   +1 more source