Results 91 to 100 of about 27,769 (271)

IL-2 Regulates CD103 Expression on CD4+ T Cells in Scurfy Mice that Display Both CD103-Dependent and Independent Inflammation [PDF]

The Journal of Immunology, 2009
Abstract Scurfy (Sf) mice lack CD4+Foxp3+ regulatory T cells and develop fatal multiorgan inflammation (MOI) mediated by CD4+ T cells. Introducing Il2−/− gene into Sf mice (Sf.Il2−/−) inhibited inflammation in skin and lung. As a major integrin receptor for the organs, we compared CD103 expression on the CD4+ T cells of B6, Il2−/−, Sf,
Rahul, Sharma, Sun-sang Joe, Sung, Christian E, Abaya, Angela Chiao-Ying, Ju, Shu Man, Fu, Shyr-Te, Ju   +5 more
openaire   +2 more sources

CD103 defines intraepithelial CD8+ PD1+ tumour-infiltrating lymphocytes of prognostic significance in endometrial adenocarcinoma [PDF]

, 2016
Introduction: Intraepithelial CD8+ tumour-infiltrating T-lymphocytes (TIL) are associated with a prolonged survival in endometrial cancer (EC). By contrast, stromal infiltration of CD8+ TIL does not confer prognostic benefit.
Hagma H. Workel, Hollema, Harry, Nijman, Hans W., Komdeur, Fenne L., Fenne L. Komdeur, Hans W. Nijman, G. Bea A. Wisman, Duiker, Evelien W., Harry Hollema, Evelien W. Duiker, Duiker, Evelien W.; id_orcid, Marco Versluis, Wisman, G. Bea A., Mourits, Marian J. E.; id_orcid, Maaike H.M. Oonk, de Bruyn, Marco; id_orcid, Eggink, Florine A., Maartje C.A. Wouters, Oonk, Maaike H. M., de Bruyn, Marco, Henriette J.G. Arts, Versluis, Marco; id_orcid, Plat, Annechien, Annechien Plat, Versluis, Marco, Wouters, Maartje C. A., Workel, Hagma H., Refika Yigit, Mourits, Marian J. E., Marian J.E. Mourits, Harry G. Klip, Klip, Harry G., Yigit, Refika, Marco de Bruyn, Arts, Henriette J. G., Florine A. Eggink   +35 more
core   +1 more source

Differential Cytotoxic Function of Resident and Non-resident CD8+ T Cells in the Human Female Reproductive Tract Before and After Menopause

Frontiers in Immunology, 2020
The functional characterization and regulation of tissue resident and non-resident CD8+ T cells in the human female reproductive tract (FRT) as women age remains a gap in our knowledge.
Marta Rodriguez-Garcia, Marta Rodriguez-Garcia, Zheng Shen, Jared M. Fortier, Charles R. Wira   +4 more
doaj   +1 more source

Dynamic landscapes of protective influenza-specific CD103+ lung resident memory CD8+ T cells revealed by intravital imaging

Immunity
SUMMARY Lung tissue-resident memory (TRM) CD8+ T-cells are critical for heterosubtypic immunity against influenza virus-(IAV)-reinfection. How TRM cells surveil the lung, respond to infection and interact with other cells remains unresolved.
S. van de Wall, S. Anthony, Lisa S. Hancox, Lecia L. Pewe, Ryan A. Langlois, D. Zehn, V. Badovinac, JT Harty   +7 more
semanticscholar   +1 more source

Autophagy Orchestrates Anti‐Tumor Immunity to Enhance Chemosensitivity via the FBXW2/C/EBPβ/TIMP‐2 Axis in Colorectal Cancer

Advanced Science, EarlyView.
Chemotherapy leverages tumor‐cell autophagy to reshape the colorectal cancer immune microenvironment. Autophagy degrades FBXW2 to promote C/EBPβ‐mediated TIMP‐2 transcription and MMP‐9 suppression, driving intra‐tumoral CD8+ T‐cell infiltration. Targeting MMP‐2/9 or restoring TIMP‐2 overcomes chemo‐resistance in autophagy‐deficient tumors. ABSTRACT The
Bing Cheng, Chaoying Wei, Zhitong Niu, Jinxin Chen, Guojie Long, Yingzhen Weng, Qiufeng Liu, Yue Jiang, Panpan Wang, Ronghua Zhang, Qiang Yu, Xiaojian Wu, Wenyu Wang   +12 more
wiley   +1 more source

The Role of CD103+ Dendritic Cells in the Intestinal Mucosal Immune System [PDF]

Frontiers in Immunology, 2011
While dendritic cells (DC) are central to the induction and regulation of adaptive immunity, these cells are very heterogenous and specific subsets can be characterized based on the expression of cell surface markers and functional properties. Intestinal CD103⁺ DCs are the subject of particular interest due to their role in regulating mucosal immunity.
Ruane, Darren Thomas, Lavelle, Ed C.
openaire   +3 more sources

Novel approach to alleviate lupus nephritis: targeting the NLRP3 inflammasome in CD8+CD69+CD103+ TRM cells

Journal of Translational Medicine
Renal CD8+ tissue-resident memory T (TRM) cells display prolonged survival and activity in lupus nephritis (LN), exacerbating renal pathology. NLRP3 regulates the T cell response.
Yi-Mei Lai, Li-Li Zhuang, Jie-Ying Zhu, Shuang Wang, Chao-Huan Guo, Binfeng Chen, Jin Li, Jia Shi, Meng-Yuan Li, N. Yang, Mianjing Zhou   +10 more
semanticscholar   +1 more source

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

Integrin αE(CD103)β7 influences cellular shape and motility in a ligand-dependent fashion

, 2008
While the extravasation cascade of lymphocytes is well characterized, data on their intraepithelial positioning and morphology are scant. However, the latter process is presumably crucial for many immune functions.
Stephanie Schlickum, Kilshaw, Peter, Helga Sennefelder, Sennefelder, Helga, Friedrich, Mike, Peter Kilshaw, Lohse, Martin J., Michael P. Schön, Schoen, Michael Peter, Gregory Harms, Mike Friedrich, Martin J. Lohse, Schlickum, Stephanie, Harms, Gregory   +13 more
core   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source