Results 71 to 80 of about 27,769 (271)

Caractérisation moléculaire et fonctionnelle des lymphocytes T CD8+/CD103+ infiltrant les tumeurs pulmonaires humaines [PDF]

, 2014
Today Immunotherapy is clearly an alternative choice in the treatment of cancers. Its main objective is to enhance the cytotoxic immune response against tumor cells while preserving normal cells. We have previously demonstrated that there is an antitumor
Djenidi, Brahim Fayçal
core   +2 more sources

Prognostic values of tissue-resident CD8+T cells in human hepatocellular carcinoma and intrahepatic cholangiocarcinoma

World Journal of Surgical Oncology, 2023
Background Tissue-resident CD8+T cells (CD103+CD8+T cells) are the essential effector cell population of anti-tumor immune response in tissue regional immunity. And we have reported that IL-33 can promote the proliferation and effector function of tissue-
Lujun Chen, Hao Huang, Ziyi Huang, Junjun Chen, Yingting Liu, Yue Wu, An Li, Junwei Ge, Zhang Fang, Bin Xu, Xiao Zheng, Changping Wu   +11 more
doaj   +1 more source

CD8+ tissue-resident memory T cells are expanded in primary Sjögren’s disease and can be therapeutically targeted by CD103 blockade

Annals of the Rheumatic Diseases
Objective Tissue-resident memory cells (Trm) are a subset of T cells residing persistently and long-term within specific tissues that contribute to persistent inflammation and tissue damage. We characterised the phenotype and function of Trm and the role
D. Mauro, Xiang Lin, E. Pontarini, Pascale Wehr, G. Guggino, Yuan Tang, Chong Deng, S. Gandolfo, F. Xiao, K. Rui, Enyu Huang, Jie Tian, S. Raimondo, M. Rischmueller, Jane Boroky, S. Downie-Doyle, H. Nel, Adriana Baz-Morelli, A. Hsu, E. Maraskovsky, A. Barr, P. Hemon, L. Chatzis, C. Boschetti, G. Colella, R. Alessandro, A. Rizzo, Jacques-Olivier Pers, M. Bombardieri, R. Thomas, Li-Wei Lu, F. Ciccia   +31 more
semanticscholar   +1 more source

Conventional Type I Migratory CD103+ Dendritic Cells are Required for Corneal Allograft Survival

Mucosal Immunology, 2023
Corneal transplant rejection is due to a T helper 1 (Th1) effector cell mediated reaction of the host toward the allogeneic tissue. Type 1 migratory conventional CD103+ dendritic cells (CD103+DC1) are known to acquire an immunosuppressive phenotype in ...
Tomás Blanco, Rohan Bir Singh, Hayate Nakagawa, Y. Taketani, Thomas H. Dohlman, Yi-He Chen, S. Chauhan, Jia Yin, Reza Danan   +8 more
semanticscholar   +1 more source

Cross-presentation of cutaneous melanoma antigen by migratory XCR1⁺CD103⁻and XCR1⁺CD103⁺dendritic cells [PDF]

OncoImmunology, 2015
The question of which dendritic cells (DCs) cross-present peripheral tumor antigens remains unanswered. We assessed the ability of multiple skin-derived and lymphoid resident DCs to perform this function in a novel orthotopic murine melanoma model where tumor establishment and expansion is within the skin.
Ben, Wylie, Elke, Seppanen, Kun, Xiao, Rachael, Zemek, Damien, Zanker, Sandro, Prato, Bree, Foley, Prue H, Hart, Richard A, Kroczek, Weisan, Chen, Jason, Waithman   +10 more
openaire   +2 more sources

CCL25 Enhances CD103-Mediated Lymphocyte Adhesion to E-Cadherin.

, 2004
Our results demonstrate that (1) CD103 is upregulated on CD8(+) T cells subsequent to their entry into the small intestinal epithelium, and (2) that the chemokine CCL25 enhances CD103-mediated adhesion to E-cadherin.
ANU ARYA, Arya, Anu, WILLIAM AGACE, ANNA ERICSSON, Agace, William, Ericsson, Anna, Ericsson, Anna,, Lund University., Agace, William,   +8 more
core   +2 more sources

Changes of CD103-expressing pulmonary CD4+ and CD8+ T cells in S. japonicum infected C57BL/6 mice

BMC Infectious Diseases, 2019
Background Recent studies have shown that CD103 is an important marker for tissue-resident memory T cells (TRM) which plays an important role in anti-infection. However, the role of CD103+ TRM was not elucidated in the progress of S.
Yi Zhao, Quan Yang, Chenxi Jin, Yuanfa Feng, Shihao Xie, Hongyan Xie, Yanwei Qi, Huaina Qiu, Hongyuan Chen, Ailin Tao, Jianbing Mu, Wenjuan Qin, Jun Huang   +12 more
doaj   +1 more source

GM-CSF and specific type 2 cytokines induce CD103+ and CD301b+ cell states in cDC1s and cDC2s.

Cell Reports
The heterogeneity of conventional dendritic cells type 1 (cDC1s) and type 2 (cDC2s) is well established, yet the identity and origin of CD301b+ cDC2s remain debated. Here, we show that CD301b+ cDC2s and CD103+ cDC1s develop from pre-committed progenitors
Lukas Amon, Damir Vurnek, Anna Seichter, G. Tchitashvili, Tomasz Kaszubowski, Markus Mroz, Nincy Debeuf, Tina Vogler, Nicole Küpper, Kaushikk Ravi Rengarajan, Lukas Lächele, N. R. Tochoedo, Anna Barańska, Stella E. Autenrieth, Falk Nimmerjahn, K. Hildner, K. Pfeffer, Barbara U. Schraml, L. Heger, B. Lambrecht, Christian H. K. Lehmann, Diana Dudziak   +21 more
semanticscholar   +1 more source

Cancer stem-like cells evade CD8+CD103+ tumor-resident memory T (TRM) lymphocytes by initiating an epithelial-to-mesenchymal transition program in a human lung tumor model

Journal for ImmunoTherapy of Cancer, 2022
Background Cancer stem cells (CSC) define a population of rare malignant cells endowed with ‘stemness’ properties, such as self-renewing, multipotency and tumorigenicity.
S. Corgnac, Isabelle Damei, G. Gros, Aziza Caidi, S. Terry, S. Chouaib, M. Deloger, F. Mami-Chouaib   +7 more
semanticscholar   +1 more source

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source